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- NCIT_C182441 IAO_0000115 "A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen desmoglein-3 (desmoglein 3; DSG3) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous DSG3 chimeric autoantibody receptor T-cells (CAART) DSG3-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing DSG3 autoantibodies. This inhibits the production of DSG3 autoantibodies. DSG3 is a protein expressed in desmosomes that plays an important role in cell adhesion. DSG3 autoantibodies are produced and expressed by aberrant B-cells in the autoimmune disease mucosal-dominant pemphigus vulgaris." @default.
- NCIT_C182441 NCIT_A7 NCIT_C101150 @default.
- NCIT_C182441 NCIT_NHC0 "C182441" @default.
- NCIT_C182441 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182441 NCIT_P107 "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART" @default.
- NCIT_C182441 NCIT_P108 "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART" @default.
- NCIT_C182441 NCIT_P208 "CL1771131" @default.
- NCIT_C182441 NCIT_P322 "CTRP" @default.
- NCIT_C182441 NCIT_P399 "809218" @default.
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- NCIT_C182441 normalizedInformationContent "100" @default.
- NCIT_C182441 referenceCount "1" @default.
- NCIT_C182441 hasExactSynonym "Autologous DSG3 CAART DSG3-CAART" @default.
- NCIT_C182441 hasExactSynonym "Autologous DSG3 Chimeric Autoantibody Receptor T-cells DSG3-CAART" @default.
- NCIT_C182441 hasExactSynonym "Autologous Desmoglein 3 Chimeric Autoantibody Receptor T Cells DSG3-CAART" @default.
- NCIT_C182441 hasExactSynonym "Autologous Desmoglein-3 CAAR-expressing T-cells DSG3-CAART" @default.
- NCIT_C182441 hasExactSynonym "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART" @default.
- NCIT_C182441 hasExactSynonym "DSG3 CAART" @default.
- NCIT_C182441 inSubset NCIT_C116977 @default.
- NCIT_C182441 inSubset NCIT_C116978 @default.
- NCIT_C182441 inSubset NCIT_C176424 @default.
- NCIT_C182441 type Class @default.
- NCIT_C182441 isDefinedBy ncit.owl @default.
- NCIT_C182441 label "Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART" @default.
- NCIT_C182441 subClassOf NCIT_C142078 @default.
- NCIT_C182441 subClassOf NCIT_C182441 @default.
- NCIT_C182441 subClassOf NCIT_C1908 @default.
- NCIT_C182441 subClassOf NCIT_C1909 @default.
- NCIT_C182441 subClassOf NCIT_C28681 @default.
- NCIT_C182441 subClassOf NCIT_C307 @default.
- NCIT_C182441 subClassOf NCIT_C308 @default.