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- NCIT_C182458 IAO_0000115 "A preparation of autologous, human immunodeficiency virus (HIV) Gag-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential antiviral activity. Autologous HIV Gag-specific CD4+ T-cells AGT103-T are prepared via ex vivo stimulation of autologous peripheral blood mononuclear cells (PBMCs) with Gag peptides, and the Gag-specific CD4+ T-cells are transduced with the recombinant lentiviral vector AGT103 encoding inhibitory RNA targeting the HIV coreceptor C-C chemokine receptor type 5 (CCR5) and HIV sequences within the Vif/Tat coding regions. Upon administration, autologous HIV Gag-specific CD4+ T-cells AGT103-T may prevent infection by CCR5- or CXCR4-tropic strains of HIV, reduce the depletion of CD4+ T-cells upon HIV exposure and prevent latently-infected cells from releasing new HIV particles." @default.
- NCIT_C182458 NCIT_NHC0 "C182458" @default.
- NCIT_C182458 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182458 NCIT_P107 "Autologous HIV Gag-specific CD4+ T-cells AGT103-T" @default.
- NCIT_C182458 NCIT_P108 "Autologous HIV Gag-specific CD4+ T-cells AGT103-T" @default.
- NCIT_C182458 NCIT_P208 "CL1771136" @default.
- NCIT_C182458 NCIT_P322 "CTRP" @default.
- NCIT_C182458 NCIT_P399 "809219" @default.
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- NCIT_C182458 NCIT_R72 NCIT_C38434 @default.
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- NCIT_C182458 NCIT_R72 NCIT_C39567 @default.
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- NCIT_C182458 normalizedInformationContent "100" @default.
- NCIT_C182458 referenceCount "1" @default.
- NCIT_C182458 hasExactSynonym "AGT103-T" @default.
- NCIT_C182458 hasExactSynonym "Autologous HIV Gag-specific CD4+ T-cells AGT103-T" @default.
- NCIT_C182458 hasExactSynonym "Autologous HIV Gag-specific CD4-positive T-lymphocytes AGT103-T" @default.
- NCIT_C182458 hasExactSynonym "Autologous HIV-specific CD4 T Cells AGT103-T" @default.
- NCIT_C182458 inSubset NCIT_C116977 @default.
- NCIT_C182458 inSubset NCIT_C116978 @default.
- NCIT_C182458 inSubset NCIT_C176424 @default.
- NCIT_C182458 type Class @default.
- NCIT_C182458 isDefinedBy ncit.owl @default.
- NCIT_C182458 label "Autologous HIV Gag-specific CD4+ T-cells AGT103-T" @default.
- NCIT_C182458 subClassOf NCIT_C142078 @default.
- NCIT_C182458 subClassOf NCIT_C182458 @default.
- NCIT_C182458 subClassOf NCIT_C1908 @default.
- NCIT_C182458 subClassOf NCIT_C1909 @default.
- NCIT_C182458 subClassOf NCIT_C28681 @default.
- NCIT_C182458 subClassOf NCIT_C307 @default.
- NCIT_C182458 subClassOf NCIT_C308 @default.