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- NCIT_C182630 IAO_0000115 "A monoclonal antibody directed against toll-like receptor 4 (TLR4), with potential anti-inflammatory activity. Upon administration, paridiprubart targets TLR4, blocks its receptor dimerization and inhibits TLR4 signaling, thereby inhibiting TLR4-mediated pro-inflammatory cytokine secretion and inflammatory response. This may reduce lung injury in acute respiratory distress syndrome (ARDS). TLR4, a member of the TLR family found on macrophages, dendritic cells (DCs) and other innate immune cells, is an important mediator of cytokine release and inflammatory response in viral infections." @default.
- NCIT_C182630 NCIT_A7 NCIT_C30105 @default.
- NCIT_C182630 NCIT_NHC0 "C182630" @default.
- NCIT_C182630 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182630 NCIT_P108 "Paridiprubart" @default.
- NCIT_C182630 NCIT_P208 "CL1770955" @default.
- NCIT_C182630 NCIT_P210 "2641646-59-3" @default.
- NCIT_C182630 NCIT_P319 "4LH8QAS0LR" @default.
- NCIT_C182630 NCIT_P322 "FDA" @default.
- NCIT_C182630 NCIT_R124 NCIT_C17710 @default.
- NCIT_C182630 NCIT_R124 NCIT_C17828 @default.
- NCIT_C182630 NCIT_R124 NCIT_C18219 @default.
- NCIT_C182630 NCIT_R124 NCIT_C19986 @default.
- NCIT_C182630 NCIT_R124 NCIT_C40474 @default.
- NCIT_C182630 normalizedInformationContent "100" @default.
- NCIT_C182630 referenceCount "1" @default.
- NCIT_C182630 hasExactSynonym "Anti-TLR4 Monoclonal Antibody EB05" @default.
- NCIT_C182630 hasExactSynonym "Anti-toll-like Receptor 4 Monoclonal Antibody EB05" @default.
- NCIT_C182630 hasExactSynonym "EB 05" @default.
- NCIT_C182630 hasExactSynonym "EB-05" @default.
- NCIT_C182630 hasExactSynonym "EB05" @default.
- NCIT_C182630 hasExactSynonym "NI-0101" @default.
- NCIT_C182630 hasExactSynonym "PARIDIPRUBART" @default.
- NCIT_C182630 hasExactSynonym "Paridiprubart" @default.
- NCIT_C182630 inSubset NCIT_C173381 @default.
- NCIT_C182630 inSubset NCIT_C173383 @default.
- NCIT_C182630 inSubset NCIT_C63923 @default.
- NCIT_C182630 type Class @default.
- NCIT_C182630 isDefinedBy ncit.owl @default.
- NCIT_C182630 label "Paridiprubart" @default.
- NCIT_C182630 subClassOf NCIT_C182630 @default.
- NCIT_C182630 subClassOf NCIT_C1908 @default.
- NCIT_C182630 subClassOf NCIT_C1909 @default.
- NCIT_C182630 subClassOf NCIT_C20401 @default.
- NCIT_C182630 subClassOf NCIT_C307 @default.
- NCIT_C182630 subClassOf NCIT_C308 @default.