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- NCIT_C18294 IAO_0000115 "Histone deacetylase 2 (488 aa, ~55 kDa) is encoded by the human HDAC2 gene. This protein plays a role in histone deacetylation, chromatin remodeling and embryonic structure development." @default.
- NCIT_C18294 NCIT_NHC0 "C18294" @default.
- NCIT_C18294 NCIT_P100 "605164" @default.
- NCIT_C18294 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C18294 NCIT_P106 "Enzyme" @default.
- NCIT_C18294 NCIT_P107 "Histone Deacetylase 2" @default.
- NCIT_C18294 NCIT_P108 "Histone Deacetylase 2" @default.
- NCIT_C18294 NCIT_P207 "C0768528" @default.
- NCIT_C18294 NCIT_P322 "CTRP" @default.
- NCIT_C18294 NCIT_P366 "Histone_Deacetylase-2" @default.
- NCIT_C18294 NCIT_P93 "Q92769" @default.
- NCIT_C18294 NCIT_P98 "One of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p, HDAC2 is found in transcription factor co-repressor complexes that include HDAC1. BRCA1 interacts with HDAC1 and HDAC2. Acetylation of histone destabilizes nucleosomes allowing transcription factors access to recognition elements in DNA. Deacetylation reseals the chromosomal package, repressing transcription. DNMT1 can establish a repressive transcription complex with HDAC2, and DMAP1. HDAC2 joins DNMT1 and DMAP1 during late S-phase, suggesting how histones may become deacetylated in heterochromatin following replication. (from OMIM 605164 and NCI)" @default.
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- NCIT_C18294 hasExactSynonym "EC 3.5.1.98" @default.
- NCIT_C18294 hasExactSynonym "HD2" @default.
- NCIT_C18294 hasExactSynonym "HDAC2" @default.
- NCIT_C18294 hasExactSynonym "Histone Deacetylase 2" @default.
- NCIT_C18294 hasExactSynonym "Transcriptional Regulator Homolog RPD3" @default.
- NCIT_C18294 hasExactSynonym "YY1-Associated Factor 1" @default.
- NCIT_C18294 inSubset NCIT_C116977 @default.
- NCIT_C18294 inSubset NCIT_C142799 @default.
- NCIT_C18294 inSubset NCIT_C142800 @default.
- NCIT_C18294 type Class @default.
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- NCIT_C18294 label "Histone Deacetylase 2" @default.
- NCIT_C18294 subClassOf NCIT_C16554 @default.
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