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- NCIT_C183133 IAO_0000115 "A preparation of T-lymphocytes that have that have been transduced with a bicistronic vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated antigen (TAA) CD19 and the other one against the TAA CD22, with potential immunomodulating and antineoplastic activities. Upon administration, the CD19x22 bicistronic CAR T-cells target, bind to and induce selective toxicity in tumor cells expressing CD19 and CD22. CD19 and CD22, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B-cells. By simultaneously targeting two B-cell antigens using two different CARs, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies." @default.
- NCIT_C183133 NCIT_A7 NCIT_C17279 @default.
- NCIT_C183133 NCIT_A7 NCIT_C38894 @default.
- NCIT_C183133 NCIT_NHC0 "C183133" @default.
- NCIT_C183133 NCIT_P106 "Cell" @default.
- NCIT_C183133 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183133 NCIT_P107 "CD19x22 Bicistronic CAR T-cells" @default.
- NCIT_C183133 NCIT_P108 "CD19x22 Bicistronic CAR T-cells" @default.
- NCIT_C183133 NCIT_P208 "CL1771364" @default.
- NCIT_C183133 NCIT_P322 "CTRP" @default.
- NCIT_C183133 NCIT_P322 "GDC" @default.
- NCIT_C183133 NCIT_P399 "809225" @default.
- NCIT_C183133 normalizedInformationContent "100" @default.
- NCIT_C183133 referenceCount "1" @default.
- NCIT_C183133 hasExactSynonym "Anti-CD19/CD22 Bicistronic CAR T-cells" @default.
- NCIT_C183133 hasExactSynonym "CD19/CD22 Bicistronic CAR-transduced T Cells" @default.
- NCIT_C183133 hasExactSynonym "CD19x22 Bicistronic CAR T-cells" @default.
- NCIT_C183133 hasExactSynonym "CD19x22 Bicistronic CAR T-lymphocytes" @default.
- NCIT_C183133 hasExactSynonym "CD19xCD22 Bicistronic CAR T-cells" @default.
- NCIT_C183133 inSubset NCIT_C116977 @default.
- NCIT_C183133 inSubset NCIT_C116978 @default.
- NCIT_C183133 inSubset NCIT_C128784 @default.
- NCIT_C183133 inSubset NCIT_C157711 @default.
- NCIT_C183133 inSubset NCIT_C157712 @default.
- NCIT_C183133 inSubset NCIT_C176424 @default.
- NCIT_C183133 type Class @default.
- NCIT_C183133 isDefinedBy ncit.owl @default.
- NCIT_C183133 label "CD19x22 Bicistronic CAR T-cells" @default.
- NCIT_C183133 subClassOf NCIT_C129820 @default.
- NCIT_C183133 subClassOf NCIT_C129821 @default.
- NCIT_C183133 subClassOf NCIT_C129826 @default.
- NCIT_C183133 subClassOf NCIT_C137999 @default.
- NCIT_C183133 subClassOf NCIT_C142078 @default.
- NCIT_C183133 subClassOf NCIT_C154231 @default.
- NCIT_C183133 subClassOf NCIT_C176018 @default.
- NCIT_C183133 subClassOf NCIT_C183133 @default.
- NCIT_C183133 subClassOf NCIT_C1908 @default.
- NCIT_C183133 subClassOf NCIT_C1909 @default.
- NCIT_C183133 subClassOf NCIT_C1962 @default.
- NCIT_C183133 subClassOf NCIT_C201173 @default.
- NCIT_C183133 subClassOf NCIT_C274 @default.
- NCIT_C183133 subClassOf NCIT_C307 @default.
- NCIT_C183133 subClassOf NCIT_C308 @default.