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- NCIT_C1832 IAO_0000115 "A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. (NCI04)" @default.
- NCIT_C1832 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1832 NCIT_NHC0 "C1832" @default.
- NCIT_C1832 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1832 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1832 NCIT_P108 "Rofecoxib" @default.
- NCIT_C1832 NCIT_P175 "720256" @default.
- NCIT_C1832 NCIT_P207 "C0762662" @default.
- NCIT_C1832 NCIT_P210 "162011-90-7" @default.
- NCIT_C1832 NCIT_P302 "Pain; dysmenorrhea; osteoarthritis; rheumatoid arthritis" @default.
- NCIT_C1832 NCIT_P319 "0QTW8Z7MCR" @default.
- NCIT_C1832 NCIT_P322 "FDA" @default.
- NCIT_C1832 NCIT_P322 "GDC" @default.
- NCIT_C1832 NCIT_P325 "A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to prevent the growth of new blood vessels that tumors need to grow. It is a type of nonsteroidal anti-inflammatory drug and a type of antiangiogenesis agent. Rofecoxib was taken off the market in the U.S. because of safety concerns." @default.
- NCIT_C1832 NCIT_P329 "38568" @default.
- NCIT_C1832 NCIT_P330 "38568" @default.
- NCIT_C1832 NCIT_P350 "C17H14O4S" @default.
- NCIT_C1832 NCIT_P366 "Rofecoxib" @default.
- NCIT_C1832 NCIT_P368 "CHEBI:8887" @default.
- NCIT_C1832 NCIT_P375 "Rofecoxib" @default.
- NCIT_C1832 NCIT_P399 "38568" @default.
- NCIT_C1832 normalizedInformationContent "100" @default.
- NCIT_C1832 referenceCount "1" @default.
- NCIT_C1832 hasExactSynonym "4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone" @default.
- NCIT_C1832 hasExactSynonym "MK 966" @default.
- NCIT_C1832 hasExactSynonym "ROFECOXIB" @default.
- NCIT_C1832 hasExactSynonym "Rofecoxib" @default.
- NCIT_C1832 hasExactSynonym "Vioxx" @default.
- NCIT_C1832 hasExactSynonym "rofecoxib" @default.
- NCIT_C1832 inSubset NCIT_C128784 @default.
- NCIT_C1832 inSubset NCIT_C157711 @default.
- NCIT_C1832 inSubset NCIT_C157712 @default.
- NCIT_C1832 inSubset NCIT_C176424 @default.
- NCIT_C1832 inSubset NCIT_C177537 @default.
- NCIT_C1832 inSubset NCIT_C63923 @default.
- NCIT_C1832 type Class @default.
- NCIT_C1832 isDefinedBy ncit.owl @default.
- NCIT_C1832 label "Rofecoxib" @default.
- NCIT_C1832 subClassOf NCIT_C1323 @default.
- NCIT_C1832 subClassOf NCIT_C1742 @default.
- NCIT_C1832 subClassOf NCIT_C1832 @default.
- NCIT_C1832 subClassOf NCIT_C1908 @default.
- NCIT_C1832 subClassOf NCIT_C1909 @default.
- NCIT_C1832 subClassOf NCIT_C2198 @default.
- NCIT_C1832 subClassOf NCIT_C2356 @default.
- NCIT_C1832 subClassOf NCIT_C241 @default.
- NCIT_C1832 subClassOf NCIT_C257 @default.
- NCIT_C1832 subClassOf NCIT_C274 @default.
- NCIT_C1832 subClassOf NCIT_C471 @default.
- NCIT_C1832 subClassOf NCIT_C78272 @default.
- NCIT_C1832 subClassOf NCIT_C80509 @default.