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- NCIT_C1833 IAO_0000115 "An orally bioavailable fluoropyrimidine antagonist composed of tegafur combined with two modulators of 5-fluorouracil (5-FU) activity, gimeracil and potassium oxonate, in a molar ratio of 1:0.4:1. Tegafur is a prodrug of 5-fluorouracil, an antimetabolite that inhibits thymidylate synthase, DNA synthesis and cell division, and competes with uridine triphosphate, thus inhibiting RNA and protein synthesis. Gimeracil is a reversible inhibitor of dihydropyrimidine dehydrogenase (DPD), the liver enzyme responsible for rapid catabolism of 5-FU into inactive metabolites. Potassium oxonate preferentially localizes in the gut and inhibits the enzyme orotate phosphoribosyl-transferase (OPRT), thereby decreasing activation of 5-FU in the gut and activated 5-FU-related gastrointestinal toxicity." @default.
- NCIT_C1833 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1833 NCIT_A7 NCIT_C17199 @default.
- NCIT_C1833 NCIT_NHC0 "C1833" @default.
- NCIT_C1833 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1833 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1833 NCIT_P107 "Tegafur-gimeracil-oteracil Potassium" @default.
- NCIT_C1833 NCIT_P108 "Tegafur-gimeracil-oteracil Potassium" @default.
- NCIT_C1833 NCIT_P171 "15224197" @default.
- NCIT_C1833 NCIT_P207 "C0879262" @default.
- NCIT_C1833 NCIT_P210 "154239-56-2" @default.
- NCIT_C1833 NCIT_P322 "CTRP" @default.
- NCIT_C1833 NCIT_P322 "GDC" @default.
- NCIT_C1833 NCIT_P325 "A drug that is being studied for its ability to enhance the effectiveness of fluorouracil and prevent gastrointestinal side effects caused by fluorouracil. It belongs to the family of drugs called antimetabolites." @default.
- NCIT_C1833 NCIT_P329 "43548" @default.
- NCIT_C1833 NCIT_P330 "43548" @default.
- NCIT_C1833 NCIT_P366 "S-1" @default.
- NCIT_C1833 NCIT_P375 "Tegafur-gimeracil-oteracil Potassium" @default.
- NCIT_C1833 NCIT_P399 "43548" @default.
- NCIT_C1833 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1833 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1833 NCIT_R124 NCIT_C28498 @default.
- NCIT_C1833 NCIT_R124 NCIT_C40576 @default.
- NCIT_C1833 NCIT_R124 NCIT_C40577 @default.
- NCIT_C1833 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1833 referenceCount "2" @default.
- NCIT_C1833 hasExactSynonym "BMS 247616" @default.
- NCIT_C1833 hasExactSynonym "BMS-247616" @default.
- NCIT_C1833 hasExactSynonym "S-1" @default.
- NCIT_C1833 hasExactSynonym "TS-1" @default.
- NCIT_C1833 hasExactSynonym "TS-One" @default.
- NCIT_C1833 hasExactSynonym "Tegafur, mixture with Gimeracil and Potassium Oxonate" @default.
- NCIT_C1833 hasExactSynonym "Tegafur-gimeracil-oteracil Potassium" @default.
- NCIT_C1833 hasExactSynonym "Tegafur/Gimeracil/Oteracil" @default.
- NCIT_C1833 hasExactSynonym "Teysuno" @default.
- NCIT_C1833 inSubset NCIT_C116977 @default.
- NCIT_C1833 inSubset NCIT_C116978 @default.
- NCIT_C1833 inSubset NCIT_C128784 @default.
- NCIT_C1833 inSubset NCIT_C157711 @default.
- NCIT_C1833 inSubset NCIT_C157712 @default.
- NCIT_C1833 inSubset NCIT_C176424 @default.
- NCIT_C1833 inSubset NCIT_C177537 @default.
- NCIT_C1833 type Class @default.
- NCIT_C1833 isDefinedBy ncit.owl @default.
- NCIT_C1833 label "Tegafur-gimeracil-oteracil Potassium" @default.
- NCIT_C1833 subClassOf B265294e99f57d0c3c6b5336fe5733ec8 @default.
- NCIT_C1833 subClassOf B7f5fb64dc4527d96154823823bfe4e04 @default.
- NCIT_C1833 subClassOf NCIT_C1557 @default.
- NCIT_C1833 subClassOf NCIT_C1833 @default.
- NCIT_C1833 subClassOf NCIT_C186664 @default.
- NCIT_C1833 subClassOf NCIT_C1908 @default.
- NCIT_C1833 subClassOf NCIT_C1909 @default.
- NCIT_C1833 subClassOf NCIT_C2019 @default.
- NCIT_C1833 subClassOf NCIT_C272 @default.
- NCIT_C1833 subClassOf NCIT_C274 @default.
- NCIT_C1833 subClassOf NCIT_C471 @default.