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- NCIT_C183319 IAO_0000115 "A pegylated, human, engineered dominant-negative tumor necrosis factor (TNF; TNF-alpha) variant devoid of TNF receptor-binding activity, with potential anti-inflammatory activity. Upon administration, pegipanermin forms heterotrimers with native soluble TNF (sTNF) but not membrane-bound transmembrane TNF (tmTNF). This prevents the binding of sTNF with TNF receptors and inhibits sTNF pro-inflammatory signaling, thereby reducing inflammation. TNF, a pro-inflammatory cytokine, is upregulated in various diseases and in cytokine storm. sTNF signaling, primarily via TNF receptor 1 (TNFR1; CD120a; p55/p60), may be responsible for exacerbation of existing inflammatory response while tmTNF signaling, primarily via TNF receptor 2 (TNFR2; CD120b; p75/p80), plays an important role in immune system development and cell survival." @default.
- NCIT_C183319 NCIT_NHC0 "C183319" @default.
- NCIT_C183319 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183319 NCIT_P108 "Pegipanermin" @default.
- NCIT_C183319 NCIT_P208 "CL1771583" @default.
- NCIT_C183319 NCIT_P210 "2489785-77-3" @default.
- NCIT_C183319 NCIT_P319 "BM6T2K8FIN" @default.
- NCIT_C183319 NCIT_P322 "FDA" @default.
- NCIT_C183319 NCIT_P399 "811121" @default.
- NCIT_C183319 NCIT_R124 NCIT_C17828 @default.
- NCIT_C183319 NCIT_R124 NCIT_C18992 @default.
- NCIT_C183319 NCIT_R124 NCIT_C19143 @default.
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- NCIT_C183319 NCIT_R125 NCIT_C17828 @default.
- NCIT_C183319 NCIT_R125 NCIT_C20150 @default.
- NCIT_C183319 NCIT_R125 NCIT_C20480 @default.
- NCIT_C183319 NCIT_R125 NCIT_C40715 @default.
- NCIT_C183319 NCIT_R125 NCIT_C41515 @default.
- NCIT_C183319 NCIT_R125 NCIT_C51037 @default.
- NCIT_C183319 NCIT_R146 NCIT_C147008 @default.
- NCIT_C183319 NCIT_R146 NCIT_C17021 @default.
- NCIT_C183319 NCIT_R146 NCIT_C17667 @default.
- NCIT_C183319 NCIT_R146 NCIT_C17728 @default.
- NCIT_C183319 NCIT_R146 NCIT_C17800 @default.
- NCIT_C183319 NCIT_R146 NCIT_C18106 @default.
- NCIT_C183319 NCIT_R146 NCIT_C19285 @default.
- NCIT_C183319 NCIT_R146 NCIT_C20027 @default.
- NCIT_C183319 NCIT_R146 NCIT_C26548 @default.
- NCIT_C183319 normalizedInformationContent "100" @default.
- NCIT_C183319 referenceCount "1" @default.
- NCIT_C183319 hasExactSynonym "DN-TNF" @default.
- NCIT_C183319 hasExactSynonym "INB03" @default.
- NCIT_C183319 hasExactSynonym "PEGIPANERMIN" @default.
- NCIT_C183319 hasExactSynonym "Pegipanermin" @default.
- NCIT_C183319 hasExactSynonym "Quellor" @default.
- NCIT_C183319 hasExactSynonym "XENP345" @default.
- NCIT_C183319 hasExactSynonym "XPro1595" @default.
- NCIT_C183319 inSubset NCIT_C173381 @default.
- NCIT_C183319 inSubset NCIT_C173383 @default.
- NCIT_C183319 inSubset NCIT_C176424 @default.
- NCIT_C183319 inSubset NCIT_C63923 @default.
- NCIT_C183319 type Class @default.
- NCIT_C183319 isDefinedBy ncit.owl @default.
- NCIT_C183319 label "Pegipanermin" @default.
- NCIT_C183319 subClassOf NCIT_C1283 @default.
- NCIT_C183319 subClassOf NCIT_C183319 @default.
- NCIT_C183319 subClassOf NCIT_C1908 @default.
- NCIT_C183319 subClassOf NCIT_C1909 @default.
- NCIT_C183319 subClassOf NCIT_C1941 @default.
- NCIT_C183319 subClassOf NCIT_C307 @default.
- NCIT_C183319 subClassOf NCIT_C308 @default.
- NCIT_C183319 subClassOf NCIT_C913 @default.