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- NCIT_C183321 IAO_0000115 "A phosphate prodrug of PF-00835231, a broad-spectrum inhibitor of coronavirus 3CL protease (3CLpro), with potential antiviral activity against coronaviruses including severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and SARS coronavirus-2 (SARS-CoV-2). Upon administration, lufotrelvir is converted to its active moiety, PF-00835231, which selectively targets and inhibits the activity of coronavirus 3CLpro. This inhibits the proteolytic cleavage of viral polyproteins and the formation of viral proteins including helicase, single-stranded-RNA-binding protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease and exoribonuclease. This prevents viral transcription and replication." @default.
- NCIT_C183321 NCIT_NHC0 "C183321" @default.
- NCIT_C183321 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183321 NCIT_P108 "Lufotrelvir" @default.
- NCIT_C183321 NCIT_P208 "CL1771581" @default.
- NCIT_C183321 NCIT_P210 "2468015-78-1" @default.
- NCIT_C183321 NCIT_P319 "XJ51YOB1SC" @default.
- NCIT_C183321 NCIT_P322 "FDA" @default.
- NCIT_C183321 normalizedInformationContent "100" @default.
- NCIT_C183321 referenceCount "1" @default.
- NCIT_C183321 hasExactSynonym "LUFOTRELVIR" @default.
- NCIT_C183321 hasExactSynonym "Lufotrelvir" @default.
- NCIT_C183321 hasExactSynonym "PF 07304814" @default.
- NCIT_C183321 hasExactSynonym "PF-07304814" @default.
- NCIT_C183321 hasExactSynonym "PF07304814" @default.
- NCIT_C183321 hasExactSynonym "WHO 12095" @default.
- NCIT_C183321 inSubset NCIT_C173381 @default.
- NCIT_C183321 inSubset NCIT_C173383 @default.
- NCIT_C183321 inSubset NCIT_C63923 @default.
- NCIT_C183321 type Class @default.
- NCIT_C183321 isDefinedBy ncit.owl @default.
- NCIT_C183321 label "Lufotrelvir" @default.
- NCIT_C183321 subClassOf NCIT_C183321 @default.
- NCIT_C183321 subClassOf NCIT_C1908 @default.
- NCIT_C183321 subClassOf NCIT_C1909 @default.
- NCIT_C183321 subClassOf NCIT_C254 @default.
- NCIT_C183321 subClassOf NCIT_C281 @default.
- NCIT_C183321 subClassOf NCIT_C471 @default.
- NCIT_C183321 subClassOf NCIT_C783 @default.