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- NCIT_C183511 IAO_0000115 "A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD70-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells." @default.
- NCIT_C183511 NCIT_A7 NCIT_C104079 @default.
- NCIT_C183511 NCIT_NHC0 "C183511" @default.
- NCIT_C183511 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183511 NCIT_P107 "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C183511 NCIT_P108 "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C183511 NCIT_P208 "CL1771884" @default.
- NCIT_C183511 NCIT_P322 "CTRP" @default.
- NCIT_C183511 NCIT_P322 "GDC" @default.
- NCIT_C183511 NCIT_P399 "808220" @default.
- NCIT_C183511 normalizedInformationContent "100" @default.
- NCIT_C183511 referenceCount "1" @default.
- NCIT_C183511 hasExactSynonym "Allogeneic Anti-CD70-CAR-IL-15-expressing CB-NK Cells" @default.
- NCIT_C183511 hasExactSynonym "Allogeneic Anti-CD70-CAR-IL-15-transduced CB-derived NK Cells" @default.
- NCIT_C183511 hasExactSynonym "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C183511 hasExactSynonym "CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells" @default.
- NCIT_C183511 hasExactSynonym "CAR.70/IL15-transduced CB-NK Cells" @default.
- NCIT_C183511 inSubset NCIT_C116977 @default.
- NCIT_C183511 inSubset NCIT_C116978 @default.
- NCIT_C183511 inSubset NCIT_C128784 @default.
- NCIT_C183511 inSubset NCIT_C157711 @default.
- NCIT_C183511 inSubset NCIT_C157712 @default.
- NCIT_C183511 inSubset NCIT_C176424 @default.
- NCIT_C183511 type Class @default.
- NCIT_C183511 isDefinedBy ncit.owl @default.
- NCIT_C183511 label "Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C183511 subClassOf NCIT_C129820 @default.
- NCIT_C183511 subClassOf NCIT_C129821 @default.
- NCIT_C183511 subClassOf NCIT_C129826 @default.
- NCIT_C183511 subClassOf NCIT_C142078 @default.
- NCIT_C183511 subClassOf NCIT_C183511 @default.
- NCIT_C183511 subClassOf NCIT_C1908 @default.
- NCIT_C183511 subClassOf NCIT_C1909 @default.
- NCIT_C183511 subClassOf NCIT_C201545 @default.
- NCIT_C183511 subClassOf NCIT_C274 @default.
- NCIT_C183511 subClassOf NCIT_C28676 @default.
- NCIT_C183511 subClassOf NCIT_C307 @default.
- NCIT_C183511 subClassOf NCIT_C308 @default.