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- NCIT_C183521 IAO_0000115 "A boosting cancer vaccine comprised of the recombinant chimeric oncolytic vesicular stomatitis virus (VSV) viral vector VSV-GP containing as of yet undisclosed peptide(s) derived from as of yet undisclosed tumor-associated antigen(s) (TAAs) that are specific for colorectal cancer (CRC) patients, with potential immunomodulating and antineoplastic activities. Upon administration, VSV-GP-based cancer vaccine VSV-GP128 preferentially replicates in tumor cells. Due to defective antiviral host defense mechanisms in tumor cells, VSV-GP is able to replicate in tumor cells without interference. This induces VSV-mediated cytolytic activity towards the tumor cells. In addition, following the administration of the priming vaccine ATP128, the booster VSV-GP-based cancer vaccine VSV-GP128 may serve to further expand and improve the phenotyping of antigen-specific T-cells targeted to tumor cells expressing the undisclosed TAA(s), thereby further killing tumor cells expressing the TAA(s). VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans but is able to rapidly replicate in and induce apoptosis of tumor cells. VSV-GP carries the envelope glycoprotein (GP) of the WE-HPI strain of the lymphocytic choriomeningitis virus (LCMV) instead of the native VSV glycoprotein (G). VSV-GP does not induce neutralizing antibodies to the vector itself, which may allow repeated administration. VSV-GP is also not neurotoxic, while wild-type viruses are associated with neural inflammation." @default.
- NCIT_C183521 NCIT_NHC0 "C183521" @default.
- NCIT_C183521 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183521 NCIT_P107 "VSV-GP-based Cancer Vaccine VSV-GP128" @default.
- NCIT_C183521 NCIT_P108 "VSV-GP-based Cancer Vaccine VSV-GP128" @default.
- NCIT_C183521 NCIT_P208 "CL1771889" @default.
- NCIT_C183521 NCIT_P322 "CTRP" @default.
- NCIT_C183521 NCIT_P322 "GDC" @default.
- NCIT_C183521 normalizedInformationContent "100" @default.
- NCIT_C183521 referenceCount "1" @default.
- NCIT_C183521 hasExactSynonym "VSV GP128" @default.
- NCIT_C183521 hasExactSynonym "VSV-GP-based Cancer Vaccine VSV-GP128" @default.
- NCIT_C183521 hasExactSynonym "VSV-GP128" @default.
- NCIT_C183521 hasExactSynonym "VSVGP128" @default.
- NCIT_C183521 hasExactSynonym "Vesicular Stomatitis Virus-GP-based Boosting Cancer Vaccine VSV-GP128" @default.
- NCIT_C183521 inSubset NCIT_C116977 @default.
- NCIT_C183521 inSubset NCIT_C116978 @default.
- NCIT_C183521 inSubset NCIT_C128784 @default.
- NCIT_C183521 inSubset NCIT_C157711 @default.
- NCIT_C183521 inSubset NCIT_C157712 @default.
- NCIT_C183521 inSubset NCIT_C176424 @default.
- NCIT_C183521 type Class @default.
- NCIT_C183521 isDefinedBy ncit.owl @default.
- NCIT_C183521 label "VSV-GP-based Cancer Vaccine VSV-GP128" @default.
- NCIT_C183521 subClassOf NCIT_C129821 @default.
- NCIT_C183521 subClassOf NCIT_C183521 @default.
- NCIT_C183521 subClassOf NCIT_C1908 @default.
- NCIT_C183521 subClassOf NCIT_C1909 @default.
- NCIT_C183521 subClassOf NCIT_C274 @default.
- NCIT_C183521 subClassOf NCIT_C307 @default.
- NCIT_C183521 subClassOf NCIT_C717 @default.