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- NCIT_C183535 IAO_0000115 "A preparation of autologous T-lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-FLT3 CAR T cells TAA05 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs)." @default.
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- NCIT_C183535 NCIT_P108 "Autologous Anti-FLT3 CAR T Cells TAA05" @default.
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- NCIT_C183535 hasExactSynonym "Autologous Anti-FLT3 CAR T Cells TAA05" @default.
- NCIT_C183535 hasExactSynonym "Autologous Anti-FMS-like Tyrosine Kinase 3 CAR T-cells TAA05" @default.
- NCIT_C183535 hasExactSynonym "Autologous FLT3-targeting CAR-T Cells TAA05" @default.
- NCIT_C183535 hasExactSynonym "TAA 05" @default.
- NCIT_C183535 hasExactSynonym "TAA-05" @default.
- NCIT_C183535 hasExactSynonym "TAA05" @default.
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- NCIT_C183535 type Class @default.
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- NCIT_C183535 label "Autologous Anti-FLT3 CAR T Cells TAA05" @default.
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