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- NCIT_C183545 IAO_0000115 "An anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody, with potential immunostimulatory and antineoplastic activities. Upon administration, nebratamig targets and binds to the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) expressed on tumor cells, the T-cell surface antigen CD3 and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) expressed on a variety of leukocyte subsets including activated T-lymphocytes. This may crosslink ROR1-expressing tumor cells and cytotoxic T-lymphocytes (CTLs) and result in a potent CTL-mediated cell lysis of ROR1-expressing tumor cells. In addition, 4-1BB binding results in T-cell co-stimulation and enhanced anti-tumor activity. At the same time, GNC-035 prevents PD-L1 from binding to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances CTL-mediated tumor cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival." @default.
- NCIT_C183545 NCIT_A7 NCIT_C29879 @default.
- NCIT_C183545 NCIT_A7 NCIT_C96024 @default.
- NCIT_C183545 NCIT_NHC0 "C183545" @default.
- NCIT_C183545 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183545 NCIT_P108 "Nebratamig" @default.
- NCIT_C183545 NCIT_P208 "CL1771906" @default.
- NCIT_C183545 NCIT_P210 "2694723-68-5" @default.
- NCIT_C183545 NCIT_P319 "A2B6R66VSJ" @default.
- NCIT_C183545 NCIT_P322 "FDA" @default.
- NCIT_C183545 NCIT_P322 "GDC" @default.
- NCIT_C183545 NCIT_P399 "806785" @default.
- NCIT_C183545 NCIT_R124 NCIT_C17710 @default.
- NCIT_C183545 NCIT_R124 NCIT_C17828 @default.
- NCIT_C183545 NCIT_R124 NCIT_C18219 @default.
- NCIT_C183545 NCIT_R124 NCIT_C19986 @default.
- NCIT_C183545 NCIT_R124 NCIT_C40474 @default.
- NCIT_C183545 normalizedInformationContent "100" @default.
- NCIT_C183545 referenceCount "1" @default.
- NCIT_C183545 hasExactSynonym "Anti-ROR1/CD3/PD-L1/4-1BB Tetra-specific Antibody GNC-035" @default.
- NCIT_C183545 hasExactSynonym "GNC 035" @default.
- NCIT_C183545 hasExactSynonym "GNC-035" @default.
- NCIT_C183545 hasExactSynonym "GNC035" @default.
- NCIT_C183545 hasExactSynonym "NEBRATAMIG" @default.
- NCIT_C183545 hasExactSynonym "Nebratamig" @default.
- NCIT_C183545 inSubset NCIT_C128784 @default.
- NCIT_C183545 inSubset NCIT_C157711 @default.
- NCIT_C183545 inSubset NCIT_C157712 @default.
- NCIT_C183545 inSubset NCIT_C176424 @default.
- NCIT_C183545 inSubset NCIT_C63923 @default.
- NCIT_C183545 type Class @default.
- NCIT_C183545 isDefinedBy ncit.owl @default.
- NCIT_C183545 label "Nebratamig" @default.
- NCIT_C183545 subClassOf NCIT_C129820 @default.
- NCIT_C183545 subClassOf NCIT_C129821 @default.
- NCIT_C183545 subClassOf NCIT_C129822 @default.
- NCIT_C183545 subClassOf NCIT_C155745 @default.
- NCIT_C183545 subClassOf NCIT_C163758 @default.
- NCIT_C183545 subClassOf NCIT_C183545 @default.
- NCIT_C183545 subClassOf NCIT_C1908 @default.
- NCIT_C183545 subClassOf NCIT_C1909 @default.
- NCIT_C183545 subClassOf NCIT_C192997 @default.
- NCIT_C183545 subClassOf NCIT_C199675 @default.
- NCIT_C183545 subClassOf NCIT_C20401 @default.
- NCIT_C183545 subClassOf NCIT_C274 @default.
- NCIT_C183545 subClassOf NCIT_C307 @default.
- NCIT_C183545 subClassOf NCIT_C308 @default.