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- NCIT_C183558 IAO_0000115 "An orally bioavailable modulator of cereblon (CRBN), part of the cullin 4-RING E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase; CUL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon oral administration, CRBN modulator TQB3820 specifically binds to CRBN, thereby affecting the ubiquitin E3 ligase activity. This leads to ubiquitination and induces proteasome-mediated degradation of the hematopoietic transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. In addition, the degradation of IKZF1 and IKZF3 may lead to the downregulation of other proteins, including interferon regulatory factor 4 (IRF4) and c-Myc, which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the E3 ubiquitin ligase complex, plays an important role in the ubiquitination of certain proteins." @default.
- NCIT_C183558 NCIT_A7 NCIT_C104142 @default.
- NCIT_C183558 NCIT_NHC0 "C183558" @default.
- NCIT_C183558 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C183558 NCIT_P108 "Cereblon Modulator TQB3820" @default.
- NCIT_C183558 NCIT_P208 "CL1771922" @default.
- NCIT_C183558 NCIT_P322 "GDC" @default.
- NCIT_C183558 NCIT_P399 "806786" @default.
- NCIT_C183558 normalizedInformationContent "100" @default.
- NCIT_C183558 referenceCount "1" @default.
- NCIT_C183558 hasExactSynonym "Cereblon Modulator TQB3820" @default.
- NCIT_C183558 hasExactSynonym "Cereblon-modulating Agent TQB3820" @default.
- NCIT_C183558 hasExactSynonym "TQB 3820" @default.
- NCIT_C183558 hasExactSynonym "TQB-3820" @default.
- NCIT_C183558 hasExactSynonym "TQB3820" @default.
- NCIT_C183558 inSubset NCIT_C128784 @default.
- NCIT_C183558 inSubset NCIT_C157711 @default.
- NCIT_C183558 inSubset NCIT_C157712 @default.
- NCIT_C183558 inSubset NCIT_C176424 @default.
- NCIT_C183558 type Class @default.
- NCIT_C183558 isDefinedBy ncit.owl @default.
- NCIT_C183558 label "Cereblon Modulator TQB3820" @default.
- NCIT_C183558 subClassOf NCIT_C183558 @default.
- NCIT_C183558 subClassOf NCIT_C1908 @default.
- NCIT_C183558 subClassOf NCIT_C1909 @default.
- NCIT_C183558 subClassOf NCIT_C308 @default.