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- NCIT_C1837 IAO_0000115 "The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness." @default.
- NCIT_C1837 NCIT_A6 NCIT_C61879 @default.
- NCIT_C1837 NCIT_NHC0 "C1837" @default.
- NCIT_C1837 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1837 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1837 NCIT_P108 "Paroxetine Hydrochloride" @default.
- NCIT_C1837 NCIT_P207 "C0771019" @default.
- NCIT_C1837 NCIT_P210 "78246-49-8" @default.
- NCIT_C1837 NCIT_P302 "Depression" @default.
- NCIT_C1837 NCIT_P319 "3I3T11UD2S" @default.
- NCIT_C1837 NCIT_P322 "FDA" @default.
- NCIT_C1837 NCIT_P325 "A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI)." @default.
- NCIT_C1837 NCIT_P329 "42793" @default.
- NCIT_C1837 NCIT_P330 "42793" @default.
- NCIT_C1837 NCIT_P350 "C19H20FNO3.HCl" @default.
- NCIT_C1837 NCIT_P366 "Paroxetine_Hydrochloride" @default.
- NCIT_C1837 NCIT_P399 "42793" @default.
- NCIT_C1837 NCIT_R122 NCIT_C16484 @default.
- NCIT_C1837 NCIT_R122 NCIT_C16486 @default.
- NCIT_C1837 NCIT_R122 NCIT_C16554 @default.
- NCIT_C1837 NCIT_R122 NCIT_C16865 @default.
- NCIT_C1837 NCIT_R122 NCIT_C16946 @default.
- NCIT_C1837 NCIT_R122 NCIT_C17021 @default.
- NCIT_C1837 NCIT_R122 NCIT_C17287 @default.
- NCIT_C1837 NCIT_R122 NCIT_C20027 @default.
- NCIT_C1837 NCIT_R122 NCIT_C26548 @default.
- NCIT_C1837 NCIT_R122 NCIT_C28459 @default.
- NCIT_C1837 normalizedInformationContent "100" @default.
- NCIT_C1837 referenceCount "1" @default.
- NCIT_C1837 hasExactSynonym "(-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Hydrochloride" @default.
- NCIT_C1837 hasExactSynonym "PAROXETINE HYDROCHLORIDE ANHYDROUS" @default.
- NCIT_C1837 hasExactSynonym "Paroxetine Hydrochloride" @default.
- NCIT_C1837 hasExactSynonym "Paxil CR" @default.
- NCIT_C1837 hasExactSynonym "Paxil" @default.
- NCIT_C1837 hasExactSynonym "paroxetine hydrochloride" @default.
- NCIT_C1837 inSubset NCIT_C176424 @default.
- NCIT_C1837 inSubset NCIT_C63923 @default.
- NCIT_C1837 type Class @default.
- NCIT_C1837 isDefinedBy ncit.owl @default.
- NCIT_C1837 label "Paroxetine Hydrochloride" @default.
- NCIT_C1837 subClassOf B2b453bb966a66a438759621d9c0957f5 @default.
- NCIT_C1837 subClassOf B61a620ae5105d62cee549735a1f26e24 @default.
- NCIT_C1837 subClassOf NCIT_C1837 @default.
- NCIT_C1837 subClassOf NCIT_C1908 @default.
- NCIT_C1837 subClassOf NCIT_C1909 @default.
- NCIT_C1837 subClassOf NCIT_C265 @default.
- NCIT_C1837 subClassOf NCIT_C78272 @default.
- NCIT_C1837 subClassOf NCIT_C94725 @default.