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- NCIT_C1839 IAO_0000115 "A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis." @default.
- NCIT_C1839 NCIT_NHC0 "C1839" @default.
- NCIT_C1839 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1839 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1839 NCIT_P108 "Lepirudin" @default.
- NCIT_C1839 NCIT_P207 "C0772394" @default.
- NCIT_C1839 NCIT_P210 "138068-37-8" @default.
- NCIT_C1839 NCIT_P319 "Y43GF64R34" @default.
- NCIT_C1839 NCIT_P322 "FDA" @default.
- NCIT_C1839 NCIT_P325 "A drug that inhibits blood clotting. It is being studied in cancer treatment." @default.
- NCIT_C1839 NCIT_P329 "43356" @default.
- NCIT_C1839 NCIT_P330 "43356" @default.
- NCIT_C1839 NCIT_P350 "C287H440N80O111S6" @default.
- NCIT_C1839 NCIT_P366 "Lepirudin" @default.
- NCIT_C1839 NCIT_P399 "43356" @default.
- NCIT_C1839 normalizedInformationContent "100" @default.
- NCIT_C1839 referenceCount "1" @default.
- NCIT_C1839 hasExactSynonym "LEPIRUDIN" @default.
- NCIT_C1839 hasExactSynonym "Lepirudin" @default.
- NCIT_C1839 hasExactSynonym "Recombinant Hirudin" @default.
- NCIT_C1839 hasExactSynonym "Refludan" @default.
- NCIT_C1839 hasExactSynonym "lepirudin" @default.
- NCIT_C1839 inSubset NCIT_C176424 @default.
- NCIT_C1839 inSubset NCIT_C63923 @default.
- NCIT_C1839 type Class @default.
- NCIT_C1839 isDefinedBy ncit.owl @default.
- NCIT_C1839 label "Lepirudin" @default.
- NCIT_C1839 subClassOf NCIT_C173066 @default.
- NCIT_C1839 subClassOf NCIT_C1839 @default.
- NCIT_C1839 subClassOf NCIT_C1908 @default.
- NCIT_C1839 subClassOf NCIT_C1909 @default.
- NCIT_C1839 subClassOf NCIT_C263 @default.
- NCIT_C1839 subClassOf NCIT_C78275 @default.