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- NCIT_C1840 IAO_0000115 "A benzonitrile derivative capable of inhibiting some prenyltransferases. L-778,123 is a dual inhibitor of farnesyl:protein and geranylgeranyl:protein transferases; both enzymes catalyze prenylation of oncoprotein KRAS, a prerequisite step in activation of KRAS in signal transduction pathway of apoptosis. Although this agent was developed in part as an anti-KRAS agent, L-778,123 failed in a Phase I trial to inhibit KRAS, which is associated with many types of solid tumors." @default.
- NCIT_C1840 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1840 NCIT_NHC0 "C1840" @default.
- NCIT_C1840 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1840 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1840 NCIT_P108 "Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123" @default.
- NCIT_C1840 NCIT_P207 "C0796327" @default.
- NCIT_C1840 NCIT_P210 "253863-00-2" @default.
- NCIT_C1840 NCIT_P319 "2A2059P49U" @default.
- NCIT_C1840 NCIT_P322 "FDA" @default.
- NCIT_C1840 NCIT_P322 "GDC" @default.
- NCIT_C1840 NCIT_P325 "An anticancer drug that belongs to the family of drugs called enzyme inhibitors. It may inhibit the transformation of normal cells into cancer cells." @default.
- NCIT_C1840 NCIT_P329 "43144" @default.
- NCIT_C1840 NCIT_P330 "43144" @default.
- NCIT_C1840 NCIT_P366 "L-778_123" @default.
- NCIT_C1840 NCIT_P375 "Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123" @default.
- NCIT_C1840 NCIT_P399 "43144" @default.
- NCIT_C1840 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1840 referenceCount "2" @default.
- NCIT_C1840 hasExactSynonym "4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile Monohydrochloride" @default.
- NCIT_C1840 hasExactSynonym "Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123" @default.
- NCIT_C1840 hasExactSynonym "L 778123" @default.
- NCIT_C1840 hasExactSynonym "L-778,123" @default.
- NCIT_C1840 hasExactSynonym "L-778123" @default.
- NCIT_C1840 inSubset NCIT_C128784 @default.
- NCIT_C1840 inSubset NCIT_C157711 @default.
- NCIT_C1840 inSubset NCIT_C157712 @default.
- NCIT_C1840 inSubset NCIT_C176424 @default.
- NCIT_C1840 inSubset NCIT_C177537 @default.
- NCIT_C1840 inSubset NCIT_C63923 @default.
- NCIT_C1840 type Class @default.
- NCIT_C1840 isDefinedBy ncit.owl @default.
- NCIT_C1840 label "Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123" @default.
- NCIT_C1840 subClassOf NCIT_C1840 @default.
- NCIT_C1840 subClassOf NCIT_C1908 @default.
- NCIT_C1840 subClassOf NCIT_C1909 @default.
- NCIT_C1840 subClassOf NCIT_C2020 @default.
- NCIT_C1840 subClassOf NCIT_C471 @default.