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- NCIT_C184308 IAO_0000115 "A radiopharmaceutical agent comprised of a pegylated cyclic arginine-glycine-aspartic acid (RGD) dimer (PRGD2) labeled with lutetium Lu 177, with potential antineoplastic activity against alphaVbeta3 integrin-expressing tumor cells. Upon administration of lutetium Lu 177 AB-3PRGD2, the RGD moiety binds to alphaVbeta3 integrin on alphaVbeta3 integrin-expressing tumor cells. The tumor cells can be eradicated upon direct cytotoxicity through beta radiation. AlphaVbeta3 integrin, a member of the integrin receptor family, is overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells; this receptor plays a key role in angiogenesis, tumor proliferation and survival." @default.
- NCIT_C184308 NCIT_A7 NCIT_C38953 @default.
- NCIT_C184308 NCIT_NHC0 "C184308" @default.
- NCIT_C184308 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184308 NCIT_P108 "Lutetium Lu 177 AB-3PRGD2" @default.
- NCIT_C184308 NCIT_P208 "CL1772608" @default.
- NCIT_C184308 NCIT_P322 "GDC" @default.
- NCIT_C184308 NCIT_P399 "806321" @default.
- NCIT_C184308 normalizedInformationContent "100" @default.
- NCIT_C184308 referenceCount "1" @default.
- NCIT_C184308 hasExactSynonym "177Lu-3PRGD2" @default.
- NCIT_C184308 hasExactSynonym "177Lu-AB-3PRGD2" @default.
- NCIT_C184308 hasExactSynonym "Lutetium Lu 177 AB-3PRGD2" @default.
- NCIT_C184308 inSubset NCIT_C128784 @default.
- NCIT_C184308 inSubset NCIT_C157711 @default.
- NCIT_C184308 inSubset NCIT_C157712 @default.
- NCIT_C184308 inSubset NCIT_C176424 @default.
- NCIT_C184308 type Class @default.
- NCIT_C184308 isDefinedBy ncit.owl @default.
- NCIT_C184308 label "Lutetium Lu 177 AB-3PRGD2" @default.
- NCIT_C184308 subClassOf NCIT_C129819 @default.
- NCIT_C184308 subClassOf NCIT_C1446 @default.
- NCIT_C184308 subClassOf NCIT_C184308 @default.
- NCIT_C184308 subClassOf NCIT_C1908 @default.
- NCIT_C184308 subClassOf NCIT_C1909 @default.
- NCIT_C184308 subClassOf NCIT_C2124 @default.
- NCIT_C184308 subClassOf NCIT_C274 @default.