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- NCIT_C184310 IAO_0000115 "A radioconjugate containing PT2385, a small molecule inhibitor of the hypoxia inducible factor (HIF)-2alpha, conjugated to the positron-emitting isotope fluorine F 18, with potential imaging activity upon positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 PT2385, the PT2385 moiety specifically targets and binds to HIF-2alpha overexpressed on tumor cells, thereby allowing the visualization of tumor cells expressing HIF-2alpha upon PET/CT. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors." @default.
- NCIT_C184310 NCIT_A7 NCIT_C104306 @default.
- NCIT_C184310 NCIT_NHC0 "C184310" @default.
- NCIT_C184310 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184310 NCIT_P108 "Fluorine F 18 PT2385" @default.
- NCIT_C184310 NCIT_P208 "CL1772622" @default.
- NCIT_C184310 normalizedInformationContent "100" @default.
- NCIT_C184310 referenceCount "1" @default.
- NCIT_C184310 hasExactSynonym "18F-PT2385" @default.
- NCIT_C184310 hasExactSynonym "Fluorine F 18 PT2385" @default.
- NCIT_C184310 hasExactSynonym "Fluorine-18 PT2385" @default.
- NCIT_C184310 hasExactSynonym "[18F]-PT2385" @default.
- NCIT_C184310 hasExactSynonym "[18F]PT2385" @default.
- NCIT_C184310 inSubset NCIT_C176424 @default.
- NCIT_C184310 type Class @default.
- NCIT_C184310 isDefinedBy ncit.owl @default.
- NCIT_C184310 label "Fluorine F 18 PT2385" @default.
- NCIT_C184310 subClassOf NCIT_C1446 @default.
- NCIT_C184310 subClassOf NCIT_C184310 @default.
- NCIT_C184310 subClassOf NCIT_C1908 @default.
- NCIT_C184310 subClassOf NCIT_C1909 @default.
- NCIT_C184310 subClassOf NCIT_C2124 @default.