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- NCIT_C18434 IAO_0000115 "Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI)" @default.
- NCIT_C18434 NCIT_NHC0 "C18434" @default.
- NCIT_C18434 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C18434 NCIT_P106 "Enzyme" @default.
- NCIT_C18434 NCIT_P107 "Topoisomerase II" @default.
- NCIT_C18434 NCIT_P108 "Topoisomerase II" @default.
- NCIT_C18434 NCIT_P207 "C0012863" @default.
- NCIT_C18434 NCIT_P322 "CTRP" @default.
- NCIT_C18434 NCIT_P366 "Topoisomerase-II" @default.
- NCIT_C18434 NCIT_P98 "DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA." @default.
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- NCIT_C18434 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C18434 referenceCount "8" @default.
- NCIT_C18434 hasExactSynonym "DNA Topoisomerase II" @default.
- NCIT_C18434 hasExactSynonym "TOP2" @default.
- NCIT_C18434 hasExactSynonym "Topo II" @default.
- NCIT_C18434 hasExactSynonym "Topoisomerase 2" @default.
- NCIT_C18434 hasExactSynonym "Topoisomerase II" @default.
- NCIT_C18434 inSubset NCIT_C116977 @default.
- NCIT_C18434 inSubset NCIT_C142799 @default.
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- NCIT_C18434 type Class @default.
- NCIT_C18434 isDefinedBy ncit.owl @default.
- NCIT_C18434 label "Topoisomerase II" @default.
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- NCIT_C18434 subClassOf NCIT_C18434 @default.
- NCIT_C18434 subClassOf NCIT_C20027 @default.
- NCIT_C18434 subClassOf NCIT_C20646 @default.
- NCIT_C18434 subClassOf NCIT_C26548 @default.