Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C184372> ?p ?o ?g. }
Showing items 1 to 39 of
39
with 100 items per page.
- NCIT_C184372 IAO_0000115 "An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), and electroporated with clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate the expression of endogenous TCR, HLA class I and HLA class II molecules, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CRISPR-edited anti-CD19 CAR T cells PACE CART19 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The removal of endogenous TCR, HLA class I and HLA class II molecules prevents allogeneic immune responses and reduces the risk of graft-versus-host disease (GvHD). The tumor-associated antigen (TAA) CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies." @default.
- NCIT_C184372 NCIT_A7 NCIT_C38894 @default.
- NCIT_C184372 NCIT_NHC0 "C184372" @default.
- NCIT_C184372 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184372 NCIT_P108 "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19" @default.
- NCIT_C184372 NCIT_P208 "CL1772549" @default.
- NCIT_C184372 NCIT_P322 "GDC" @default.
- NCIT_C184372 NCIT_P399 "806792" @default.
- NCIT_C184372 normalizedInformationContent "100" @default.
- NCIT_C184372 referenceCount "1" @default.
- NCIT_C184372 hasExactSynonym "Allogeneic Anti-CD19 CAR T Cells PACE CART19" @default.
- NCIT_C184372 hasExactSynonym "Allogeneic Anti-CD19 CAR T-cells PACE CART19" @default.
- NCIT_C184372 hasExactSynonym "Allogeneic Anti-CD19 CAR-T Cells PACE CART19" @default.
- NCIT_C184372 hasExactSynonym "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19" @default.
- NCIT_C184372 hasExactSynonym "PACE CART19 Cells" @default.
- NCIT_C184372 hasExactSynonym "PACE CART19" @default.
- NCIT_C184372 inSubset NCIT_C128784 @default.
- NCIT_C184372 inSubset NCIT_C157711 @default.
- NCIT_C184372 inSubset NCIT_C157712 @default.
- NCIT_C184372 inSubset NCIT_C176424 @default.
- NCIT_C184372 type Class @default.
- NCIT_C184372 isDefinedBy ncit.owl @default.
- NCIT_C184372 label "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PACE CART19" @default.
- NCIT_C184372 subClassOf NCIT_C129820 @default.
- NCIT_C184372 subClassOf NCIT_C129821 @default.
- NCIT_C184372 subClassOf NCIT_C129826 @default.
- NCIT_C184372 subClassOf NCIT_C137999 @default.
- NCIT_C184372 subClassOf NCIT_C142078 @default.
- NCIT_C184372 subClassOf NCIT_C154231 @default.
- NCIT_C184372 subClassOf NCIT_C176018 @default.
- NCIT_C184372 subClassOf NCIT_C184372 @default.
- NCIT_C184372 subClassOf NCIT_C1908 @default.
- NCIT_C184372 subClassOf NCIT_C1909 @default.
- NCIT_C184372 subClassOf NCIT_C1962 @default.
- NCIT_C184372 subClassOf NCIT_C200765 @default.
- NCIT_C184372 subClassOf NCIT_C274 @default.
- NCIT_C184372 subClassOf NCIT_C28676 @default.
- NCIT_C184372 subClassOf NCIT_C307 @default.
- NCIT_C184372 subClassOf NCIT_C308 @default.