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- NCIT_C184373 IAO_0000115 "An orally bioavailable inhibitor of the serine/threonine kinase protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK; eukaryotic translation initiation factor 2-alpha kinase 3; EIF2AK3; PEK), with potential antineoplastic activity. Upon oral administration, PERK inhibitor NMS-03597812 inhibits the activity of PERK. This prevents the activation of the PERK pathway and inhibits unfolded protein response (UPR) stress adaptation, which may lead to tumor cell apoptosis and the inhibition of tumor growth. PERK, one of the key sensors for the UPR, plays a key role in the response to and resolution of endoplasmic reticulum (ER) stress and also in tumor angiogenesis and survival." @default.
- NCIT_C184373 NCIT_A7 NCIT_C102829 @default.
- NCIT_C184373 NCIT_NHC0 "C184373" @default.
- NCIT_C184373 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184373 NCIT_P107 "PERK Inhibitor NMS-03597812" @default.
- NCIT_C184373 NCIT_P108 "PERK Inhibitor NMS-03597812" @default.
- NCIT_C184373 NCIT_P208 "CL1772562" @default.
- NCIT_C184373 NCIT_P322 "CTRP" @default.
- NCIT_C184373 NCIT_P322 "GDC" @default.
- NCIT_C184373 NCIT_P399 "806793" @default.
- NCIT_C184373 normalizedInformationContent "100" @default.
- NCIT_C184373 referenceCount "1" @default.
- NCIT_C184373 hasExactSynonym "NMS 03597812" @default.
- NCIT_C184373 hasExactSynonym "NMS-03597812" @default.
- NCIT_C184373 hasExactSynonym "NMS03597812" @default.
- NCIT_C184373 hasExactSynonym "PERK Inhibitor NMS-03597812" @default.
- NCIT_C184373 inSubset NCIT_C116977 @default.
- NCIT_C184373 inSubset NCIT_C116978 @default.
- NCIT_C184373 inSubset NCIT_C128784 @default.
- NCIT_C184373 inSubset NCIT_C157711 @default.
- NCIT_C184373 inSubset NCIT_C157712 @default.
- NCIT_C184373 inSubset NCIT_C176424 @default.
- NCIT_C184373 type Class @default.
- NCIT_C184373 isDefinedBy ncit.owl @default.
- NCIT_C184373 label "PERK Inhibitor NMS-03597812" @default.
- NCIT_C184373 subClassOf NCIT_C129824 @default.
- NCIT_C184373 subClassOf NCIT_C129825 @default.
- NCIT_C184373 subClassOf NCIT_C184373 @default.
- NCIT_C184373 subClassOf NCIT_C1908 @default.
- NCIT_C184373 subClassOf NCIT_C1909 @default.
- NCIT_C184373 subClassOf NCIT_C2189 @default.
- NCIT_C184373 subClassOf NCIT_C274 @default.
- NCIT_C184373 subClassOf NCIT_C471 @default.