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- NCIT_C184375 IAO_0000115 "A recombinant bispecific antibody targeting both the immunosuppressive ligand human programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) and the human transforming growth factor beta (TGF-beta), with potential antineoplastic and immune checkpoint modulating activities. Upon administration, the anti-PD-L1/TGF-beta bispecific antibody Y101D targets, binds to and neutralizes TGFbeta while simultaneously targets, binds to, and inhibits the activity of PD-L1 on tumor cells. This prevents both TGF-beta- and PD-L1-mediated immuno-suppressive pathways signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This restores and enhances anti-tumor responses and inhibits tumor cell proliferation in susceptible tumor cells. TGF-beta and PD-L1 are both upregulated in certain types of cancers; their overexpression is associated with increased evasion of immune surveillance and contributes to poor prognosis." @default.
- NCIT_C184375 NCIT_A7 NCIT_C20455 @default.
- NCIT_C184375 NCIT_A7 NCIT_C96024 @default.
- NCIT_C184375 NCIT_NHC0 "C184375" @default.
- NCIT_C184375 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184375 NCIT_P108 "Anti-PD-L1/TGF-beta Bispecific Antibody Y101D" @default.
- NCIT_C184375 NCIT_P208 "CL1772560" @default.
- NCIT_C184375 NCIT_P322 "GDC" @default.
- NCIT_C184375 NCIT_P399 "806797" @default.
- NCIT_C184375 NCIT_R124 NCIT_C17710 @default.
- NCIT_C184375 NCIT_R124 NCIT_C17828 @default.
- NCIT_C184375 NCIT_R124 NCIT_C18219 @default.
- NCIT_C184375 NCIT_R124 NCIT_C19986 @default.
- NCIT_C184375 NCIT_R124 NCIT_C40474 @default.
- NCIT_C184375 normalizedInformationContent "100" @default.
- NCIT_C184375 referenceCount "1" @default.
- NCIT_C184375 hasExactSynonym "Anti-PD-L1/Anti-TGF-beta Bispecific Antibody Y101D" @default.
- NCIT_C184375 hasExactSynonym "Anti-PD-L1/TGF-beta Bispecific Antibody Y101D" @default.
- NCIT_C184375 hasExactSynonym "PD-L1 x TGFbeta Bispecific Antibody Y101D" @default.
- NCIT_C184375 hasExactSynonym "PD-L1/TGF-beta Bispecific Antibody Y101D" @default.
- NCIT_C184375 hasExactSynonym "Y 101D" @default.
- NCIT_C184375 hasExactSynonym "Y-101D" @default.
- NCIT_C184375 hasExactSynonym "Y101D" @default.
- NCIT_C184375 inSubset NCIT_C128784 @default.
- NCIT_C184375 inSubset NCIT_C157711 @default.
- NCIT_C184375 inSubset NCIT_C157712 @default.
- NCIT_C184375 inSubset NCIT_C176424 @default.
- NCIT_C184375 type Class @default.
- NCIT_C184375 isDefinedBy ncit.owl @default.
- NCIT_C184375 label "Anti-PD-L1/TGF-beta Bispecific Antibody Y101D" @default.
- NCIT_C184375 subClassOf NCIT_C128057 @default.
- NCIT_C184375 subClassOf NCIT_C141144 @default.
- NCIT_C184375 subClassOf NCIT_C143250 @default.
- NCIT_C184375 subClassOf NCIT_C1454 @default.
- NCIT_C184375 subClassOf NCIT_C156893 @default.
- NCIT_C184375 subClassOf NCIT_C163758 @default.
- NCIT_C184375 subClassOf NCIT_C184375 @default.
- NCIT_C184375 subClassOf NCIT_C1908 @default.
- NCIT_C184375 subClassOf NCIT_C1909 @default.
- NCIT_C184375 subClassOf NCIT_C191689 @default.
- NCIT_C184375 subClassOf NCIT_C20401 @default.
- NCIT_C184375 subClassOf NCIT_C274 @default.
- NCIT_C184375 subClassOf NCIT_C307 @default.
- NCIT_C184375 subClassOf NCIT_C308 @default.