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- NCIT_C184376 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) agonistic monoclonal antibody targeting the costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD137 agonistic monoclonal antibody YH004 targets and binds to CD137, thereby activating CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated tumor cell killing and suppresses the immunosuppressive activity of T-regulatory cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C184376 NCIT_A7 NCIT_C105113 @default.
- NCIT_C184376 NCIT_NHC0 "C184376" @default.
- NCIT_C184376 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184376 NCIT_P108 "Anti-CD137 Agonistic Monoclonal Antibody YH004" @default.
- NCIT_C184376 NCIT_P208 "CL1772561" @default.
- NCIT_C184376 NCIT_P322 "GDC" @default.
- NCIT_C184376 NCIT_P399 "806802" @default.
- NCIT_C184376 NCIT_R124 NCIT_C17710 @default.
- NCIT_C184376 NCIT_R124 NCIT_C17828 @default.
- NCIT_C184376 NCIT_R124 NCIT_C18219 @default.
- NCIT_C184376 NCIT_R124 NCIT_C19986 @default.
- NCIT_C184376 NCIT_R124 NCIT_C40474 @default.
- NCIT_C184376 normalizedInformationContent "100" @default.
- NCIT_C184376 referenceCount "1" @default.
- NCIT_C184376 hasExactSynonym "Anti-4-1BB Monoclonal Antibody YH004" @default.
- NCIT_C184376 hasExactSynonym "Anti-CD137 Agonistic Monoclonal Antibody YH004" @default.
- NCIT_C184376 hasExactSynonym "YH 004" @default.
- NCIT_C184376 hasExactSynonym "YH-004" @default.
- NCIT_C184376 hasExactSynonym "YH004" @default.
- NCIT_C184376 inSubset NCIT_C128784 @default.
- NCIT_C184376 inSubset NCIT_C157711 @default.
- NCIT_C184376 inSubset NCIT_C157712 @default.
- NCIT_C184376 inSubset NCIT_C176424 @default.
- NCIT_C184376 type Class @default.
- NCIT_C184376 isDefinedBy ncit.owl @default.
- NCIT_C184376 label "Anti-CD137 Agonistic Monoclonal Antibody YH004" @default.
- NCIT_C184376 subClassOf NCIT_C129820 @default.
- NCIT_C184376 subClassOf NCIT_C155745 @default.
- NCIT_C184376 subClassOf NCIT_C184376 @default.
- NCIT_C184376 subClassOf NCIT_C1908 @default.
- NCIT_C184376 subClassOf NCIT_C1909 @default.
- NCIT_C184376 subClassOf NCIT_C192997 @default.
- NCIT_C184376 subClassOf NCIT_C20401 @default.
- NCIT_C184376 subClassOf NCIT_C274 @default.
- NCIT_C184376 subClassOf NCIT_C307 @default.
- NCIT_C184376 subClassOf NCIT_C308 @default.