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- NCIT_C1844 IAO_0000115 "An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors." @default.
- NCIT_C1844 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1844 NCIT_A7 NCIT_C38929 @default.
- NCIT_C1844 NCIT_NHC0 "C1844" @default.
- NCIT_C1844 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1844 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1844 NCIT_P107 "Temsirolimus" @default.
- NCIT_C1844 NCIT_P108 "Temsirolimus" @default.
- NCIT_C1844 NCIT_P175 "683864" @default.
- NCIT_C1844 NCIT_P207 "C1707080" @default.
- NCIT_C1844 NCIT_P210 "162635-04-3" @default.
- NCIT_C1844 NCIT_P302 "Advanced renal cell carcinoma" @default.
- NCIT_C1844 NCIT_P302 "Renal Cell Carcinoma" @default.
- NCIT_C1844 NCIT_P319 "624KN6GM2T" @default.
- NCIT_C1844 NCIT_P322 "CTRP" @default.
- NCIT_C1844 NCIT_P322 "FDA" @default.
- NCIT_C1844 NCIT_P322 "GDC" @default.
- NCIT_C1844 NCIT_P325 "A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein involved in cell division, and may kill cancer cells. It is a type of rapamycin analog and a type of serine/threonine kinase inhibitor." @default.
- NCIT_C1844 NCIT_P329 "43369" @default.
- NCIT_C1844 NCIT_P330 "43369" @default.
- NCIT_C1844 NCIT_P350 "C56H87NO16" @default.
- NCIT_C1844 NCIT_P366 "CCI-779" @default.
- NCIT_C1844 NCIT_P375 "Temsirolimus" @default.
- NCIT_C1844 NCIT_P399 "43369" @default.
- NCIT_C1844 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1844 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1844 NCIT_R124 NCIT_C28498 @default.
- NCIT_C1844 NCIT_R124 NCIT_C40576 @default.
- NCIT_C1844 NCIT_R124 NCIT_C40577 @default.
- NCIT_C1844 NCIT_R125 NCIT_C16397 @default.
- NCIT_C1844 NCIT_R125 NCIT_C16750 @default.
- NCIT_C1844 NCIT_R125 NCIT_C17133 @default.
- NCIT_C1844 NCIT_R125 NCIT_C17355 @default.
- NCIT_C1844 NCIT_R125 NCIT_C17710 @default.
- NCIT_C1844 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1844 NCIT_R125 NCIT_C19077 @default.
- NCIT_C1844 NCIT_R125 NCIT_C19816 @default.
- NCIT_C1844 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1844 NCIT_R125 NCIT_C21049 @default.
- NCIT_C1844 NCIT_R125 NCIT_C21050 @default.
- NCIT_C1844 NCIT_R125 NCIT_C21102 @default.
- NCIT_C1844 NCIT_R125 NCIT_C28498 @default.
- NCIT_C1844 NCIT_R125 NCIT_C40692 @default.
- NCIT_C1844 NCIT_R125 NCIT_C40821 @default.
- NCIT_C1844 NCIT_R146 NCIT_C16554 @default.
- NCIT_C1844 NCIT_R146 NCIT_C16984 @default.
- NCIT_C1844 NCIT_R146 NCIT_C17018 @default.
- NCIT_C1844 NCIT_R146 NCIT_C17021 @default.
- NCIT_C1844 NCIT_R146 NCIT_C17210 @default.
- NCIT_C1844 NCIT_R146 NCIT_C17325 @default.
- NCIT_C1844 NCIT_R146 NCIT_C20027 @default.
- NCIT_C1844 NCIT_R146 NCIT_C26548 @default.
- NCIT_C1844 NCIT_R146 NCIT_C38929 @default.
- NCIT_C1844 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C1844 referenceCount "5" @default.
- NCIT_C1844 hasExactSynonym "42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin" @default.
- NCIT_C1844 hasExactSynonym "CCI-779 Rapamycin Analog" @default.
- NCIT_C1844 hasExactSynonym "CCI-779" @default.
- NCIT_C1844 hasExactSynonym "Cell Cycle Inhibitor 779" @default.
- NCIT_C1844 hasExactSynonym "Rapamycin Analog CCI-779" @default.
- NCIT_C1844 hasExactSynonym "Rapamycin Analog" @default.
- NCIT_C1844 hasExactSynonym "TEMSIROLIMUS" @default.
- NCIT_C1844 hasExactSynonym "Temsirolimus" @default.
- NCIT_C1844 hasExactSynonym "Torisel" @default.
- NCIT_C1844 hasExactSynonym "temsirolimus" @default.
- NCIT_C1844 inSubset NCIT_C116977 @default.
- NCIT_C1844 inSubset NCIT_C116978 @default.
- NCIT_C1844 inSubset NCIT_C128784 @default.
- NCIT_C1844 inSubset NCIT_C157711 @default.
- NCIT_C1844 inSubset NCIT_C157712 @default.
- NCIT_C1844 inSubset NCIT_C176424 @default.
- NCIT_C1844 inSubset NCIT_C177537 @default.
- NCIT_C1844 inSubset NCIT_C63923 @default.
- NCIT_C1844 type Class @default.
- NCIT_C1844 isDefinedBy ncit.owl @default.
- NCIT_C1844 label "Temsirolimus" @default.
- NCIT_C1844 subClassOf NCIT_C1404 @default.
- NCIT_C1844 subClassOf NCIT_C163758 @default.
- NCIT_C1844 subClassOf NCIT_C1844 @default.
- NCIT_C1844 subClassOf NCIT_C1908 @default.
- NCIT_C1844 subClassOf NCIT_C1909 @default.
- NCIT_C1844 subClassOf NCIT_C2201 @default.
- NCIT_C1844 subClassOf NCIT_C274 @default.
- NCIT_C1844 subClassOf NCIT_C471 @default.
- NCIT_C1844 subClassOf NCIT_C61074 @default.
- NCIT_C1844 equivalentClass B751dd79245914b632d5ef6e2e060e523 @default.
- NCIT_C1844 equivalentClass B9c7c828f004b9d4262b16b7bc06adb77 @default.