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- NCIT_C184829 IAO_0000115 "A half-life extended (HLE), bispecific T-cell engager (BiTE) antibody directed against the tumor-associated antigen (TAA) claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, gresonitamab simultaneously binds to both CD3-expressing T-cells and CLDN18.2-expressing cancer cells, thereby crosslinking CLDN18.2-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C184829 NCIT_A32 NCIT_C1909 @default.
- NCIT_C184829 NCIT_A7 NCIT_C150412 @default.
- NCIT_C184829 NCIT_NHC0 "C184829" @default.
- NCIT_C184829 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C184829 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184829 NCIT_P107 "Gresonitamab" @default.
- NCIT_C184829 NCIT_P108 "Gresonitamab" @default.
- NCIT_C184829 NCIT_P208 "CL1382994" @default.
- NCIT_C184829 NCIT_P210 "2413817-97-5" @default.
- NCIT_C184829 NCIT_P319 "0SIB91V6TP" @default.
- NCIT_C184829 NCIT_P322 "CTRP" @default.
- NCIT_C184829 NCIT_P322 "FDA" @default.
- NCIT_C184829 NCIT_P322 "GDC" @default.
- NCIT_C184829 NCIT_P375 "BiTE Antibody AMG 910" @default.
- NCIT_C184829 NCIT_P399 "801178" @default.
- NCIT_C184829 NCIT_R124 NCIT_C17710 @default.
- NCIT_C184829 NCIT_R124 NCIT_C17828 @default.
- NCIT_C184829 NCIT_R124 NCIT_C18219 @default.
- NCIT_C184829 NCIT_R124 NCIT_C19986 @default.
- NCIT_C184829 NCIT_R124 NCIT_C40474 @default.
- NCIT_C184829 normalizedInformationContent "100" @default.
- NCIT_C184829 referenceCount "1" @default.
- NCIT_C184829 hasExactSynonym "AMG 910" @default.
- NCIT_C184829 hasExactSynonym "AMG-910" @default.
- NCIT_C184829 hasExactSynonym "AMG910" @default.
- NCIT_C184829 hasExactSynonym "BiTE Antibody AMG 910" @default.
- NCIT_C184829 hasExactSynonym "Bispecific Antibody AMG 910" @default.
- NCIT_C184829 hasExactSynonym "Bispecific T-cell Engager AMG 910" @default.
- NCIT_C184829 hasExactSynonym "Bispecific T-cell Engager Antibody AMG 910" @default.
- NCIT_C184829 hasExactSynonym "GRESONITAMAB" @default.
- NCIT_C184829 hasExactSynonym "Gresonitamab" @default.
- NCIT_C184829 inSubset NCIT_C116977 @default.
- NCIT_C184829 inSubset NCIT_C116978 @default.
- NCIT_C184829 inSubset NCIT_C128784 @default.
- NCIT_C184829 inSubset NCIT_C157711 @default.
- NCIT_C184829 inSubset NCIT_C157712 @default.
- NCIT_C184829 inSubset NCIT_C176424 @default.
- NCIT_C184829 inSubset NCIT_C177537 @default.
- NCIT_C184829 inSubset NCIT_C63923 @default.
- NCIT_C184829 type Class @default.
- NCIT_C184829 isDefinedBy ncit.owl @default.
- NCIT_C184829 label "Gresonitamab" @default.
- NCIT_C184829 subClassOf NCIT_C112883 @default.
- NCIT_C184829 subClassOf NCIT_C129821 @default.
- NCIT_C184829 subClassOf NCIT_C129822 @default.
- NCIT_C184829 subClassOf NCIT_C1454 @default.
- NCIT_C184829 subClassOf NCIT_C184829 @default.
- NCIT_C184829 subClassOf NCIT_C1908 @default.
- NCIT_C184829 subClassOf NCIT_C1909 @default.
- NCIT_C184829 subClassOf NCIT_C201282 @default.
- NCIT_C184829 subClassOf NCIT_C20401 @default.
- NCIT_C184829 subClassOf NCIT_C274 @default.
- NCIT_C184829 subClassOf NCIT_C28227 @default.
- NCIT_C184829 subClassOf NCIT_C307 @default.
- NCIT_C184829 subClassOf NCIT_C308 @default.