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- NCIT_C184865 IAO_0000115 "A bispecific antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and the human vascular endothelial growth factor (VEGF), with potential immune checkpoint inhibitory, anti-angiogenic and antineoplastic activities. Upon administration, ivonescimab simultaneously targets and binds to both PD-1 expressed on certain T-cells and VEGF expressed on tumor cells. The binding of ivonescimab to PD-1 prevents the activation of PD-1 by its ligands, programmed cell death-1 ligand 1 (PD-L1; CD274) and/or 2 (PD-L2; CD273). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis, which may lead to a reduction in tumor growth. The binding of ivonescimab to VEGF prevents binding of VEGF to its receptor VEGFR, abrogates VEGF/VEGFR-mediated signaling and may lead to the inhibition of vascular endothelial cell proliferation. The inhibition of tumor angiogenesis may further decrease tumor cell proliferation and prevent metastasis. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands PD-L1 and/or PD-L2; it plays an important role in tumor evasion from host immunity. VEGF is overexpressed in a variety of cancers and is associated with increased invasiveness and decreased survival." @default.
- NCIT_C184865 NCIT_A32 NCIT_C1909 @default.
- NCIT_C184865 NCIT_A7 NCIT_C129646 @default.
- NCIT_C184865 NCIT_A7 NCIT_C94697 @default.
- NCIT_C184865 NCIT_NHC0 "C184865" @default.
- NCIT_C184865 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C184865 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184865 NCIT_P108 "Ivonescimab" @default.
- NCIT_C184865 NCIT_P208 "CL1772938" @default.
- NCIT_C184865 NCIT_P210 "2428381-53-5" @default.
- NCIT_C184865 NCIT_P319 "Y0O332CU66" @default.
- NCIT_C184865 NCIT_P322 "FDA" @default.
- NCIT_C184865 NCIT_P322 "GDC" @default.
- NCIT_C184865 NCIT_P375 "Anti-PD-1/VEGF Bispecific Antibody AK112" @default.
- NCIT_C184865 NCIT_P399 "800843" @default.
- NCIT_C184865 NCIT_R124 NCIT_C17710 @default.
- NCIT_C184865 NCIT_R124 NCIT_C17828 @default.
- NCIT_C184865 NCIT_R124 NCIT_C18219 @default.
- NCIT_C184865 NCIT_R124 NCIT_C19986 @default.
- NCIT_C184865 NCIT_R124 NCIT_C40474 @default.
- NCIT_C184865 normalizedInformationContent "100" @default.
- NCIT_C184865 referenceCount "1" @default.
- NCIT_C184865 hasExactSynonym "AK 112" @default.
- NCIT_C184865 hasExactSynonym "AK-112" @default.
- NCIT_C184865 hasExactSynonym "AK112" @default.
- NCIT_C184865 hasExactSynonym "Anti-PD-1/Anti-VEGF Bispecific Antibody AK112" @default.
- NCIT_C184865 hasExactSynonym "Anti-PD-1/VEGF Bispecific Antibody AK112" @default.
- NCIT_C184865 hasExactSynonym "IVONESCIMAB" @default.
- NCIT_C184865 hasExactSynonym "Ivonescimab" @default.
- NCIT_C184865 hasExactSynonym "PD-1/VEGF Bispecific Antibody AK112" @default.
- NCIT_C184865 hasExactSynonym "SMT 112" @default.
- NCIT_C184865 hasExactSynonym "SMT-112" @default.
- NCIT_C184865 hasExactSynonym "SMT112" @default.
- NCIT_C184865 inSubset NCIT_C128784 @default.
- NCIT_C184865 inSubset NCIT_C157711 @default.
- NCIT_C184865 inSubset NCIT_C157712 @default.
- NCIT_C184865 inSubset NCIT_C176424 @default.
- NCIT_C184865 inSubset NCIT_C177537 @default.
- NCIT_C184865 inSubset NCIT_C63923 @default.
- NCIT_C184865 type Class @default.
- NCIT_C184865 isDefinedBy ncit.owl @default.
- NCIT_C184865 label "Ivonescimab" @default.
- NCIT_C184865 subClassOf NCIT_C124946 @default.
- NCIT_C184865 subClassOf NCIT_C128037 @default.
- NCIT_C184865 subClassOf NCIT_C129821 @default.
- NCIT_C184865 subClassOf NCIT_C129822 @default.
- NCIT_C184865 subClassOf NCIT_C141144 @default.
- NCIT_C184865 subClassOf NCIT_C143250 @default.
- NCIT_C184865 subClassOf NCIT_C1454 @default.
- NCIT_C184865 subClassOf NCIT_C163758 @default.
- NCIT_C184865 subClassOf NCIT_C1742 @default.
- NCIT_C184865 subClassOf NCIT_C184865 @default.
- NCIT_C184865 subClassOf NCIT_C1908 @default.
- NCIT_C184865 subClassOf NCIT_C1909 @default.
- NCIT_C184865 subClassOf NCIT_C198860 @default.
- NCIT_C184865 subClassOf NCIT_C20401 @default.
- NCIT_C184865 subClassOf NCIT_C2496 @default.
- NCIT_C184865 subClassOf NCIT_C274 @default.
- NCIT_C184865 subClassOf NCIT_C28227 @default.
- NCIT_C184865 subClassOf NCIT_C307 @default.
- NCIT_C184865 subClassOf NCIT_C308 @default.