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- NCIT_C184944 IAO_0000115 "An imaging agent composed of a pH-low insertion peptide (pHLIP) probe coupled with the near infrared (NIR) fluorescent dye indocyanine green (ICG), that may be used for cancer imaging using NIR imaging. Upon administration of pHLIP-ICG during surgery, the pHLIP moiety specifically targets and gets inserted into the cellular membrane of tumor cells as the tumor cell environments are more acidic than normal, healthy tissue environments. More specifically, the pHLIP forms an alpha helix and becomes inserted across the cell membrane specifically at the low extracellular pH found within tumors whereas they are unfolded and unbound at higher pHs. Upon NIR imaging, tumor cells and the extent of acidity can be visualized and assessed, marking the tumor cells for surgical removal." @default.
- NCIT_C184944 NCIT_NHC0 "C184944" @default.
- NCIT_C184944 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C184944 NCIT_P107 "pH-Low Insertion Peptide-Indocyanine Green" @default.
- NCIT_C184944 NCIT_P108 "pH-Low Insertion Peptide-Indocyanine Green" @default.
- NCIT_C184944 NCIT_P208 "CL1772896" @default.
- NCIT_C184944 NCIT_P322 "CTRP" @default.
- NCIT_C184944 NCIT_P399 "809209" @default.
- NCIT_C184944 normalizedInformationContent "100" @default.
- NCIT_C184944 referenceCount "1" @default.
- NCIT_C184944 hasExactSynonym "ICG pHLIP (R)" @default.
- NCIT_C184944 hasExactSynonym "pH-Low Insertion Peptide-ICG" @default.
- NCIT_C184944 hasExactSynonym "pH-Low Insertion Peptide-Indocyanine Green" @default.
- NCIT_C184944 hasExactSynonym "pHLIP (R)-ICG" @default.
- NCIT_C184944 inSubset NCIT_C116977 @default.
- NCIT_C184944 inSubset NCIT_C116978 @default.
- NCIT_C184944 inSubset NCIT_C176424 @default.
- NCIT_C184944 type Class @default.
- NCIT_C184944 isDefinedBy ncit.owl @default.
- NCIT_C184944 label "pH-Low Insertion Peptide-Indocyanine Green" @default.
- NCIT_C184944 subClassOf NCIT_C184944 @default.
- NCIT_C184944 subClassOf NCIT_C1908 @default.
- NCIT_C184944 subClassOf NCIT_C1966 @default.
- NCIT_C184944 subClassOf NCIT_C45678 @default.
- NCIT_C184944 subClassOf NCIT_C802 @default.