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- NCIT_C184955 IAO_0000115 "The hydrate form of regorafenib, an orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling." @default.
- NCIT_C184955 NCIT_A7 NCIT_C17322 @default.
- NCIT_C184955 NCIT_A7 NCIT_C17328 @default.
- NCIT_C184955 NCIT_A7 NCIT_C17484 @default.
- NCIT_C184955 NCIT_A7 NCIT_C18539 @default.
- NCIT_C184955 NCIT_A7 NCIT_C26203 @default.
- NCIT_C184955 NCIT_A7 NCIT_C28496 @default.
- NCIT_C184955 NCIT_NHC0 "C184955" @default.
- NCIT_C184955 NCIT_P106 "Organic Chemical" @default.
- NCIT_C184955 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C184955 NCIT_P107 "Regorafenib" @default.
- NCIT_C184955 NCIT_P108 "Regorafenib Hydrate" @default.
- NCIT_C184955 NCIT_P208 "CL1772908" @default.
- NCIT_C184955 NCIT_P210 "1019206-88-2" @default.
- NCIT_C184955 NCIT_P302 "hepatocellular carcinoma (HCC)" @default.
- NCIT_C184955 NCIT_P319 "MGN125FS9D" @default.
- NCIT_C184955 NCIT_P322 "CTRP" @default.
- NCIT_C184955 NCIT_P322 "FDA" @default.
- NCIT_C184955 NCIT_P322 "GDC" @default.
- NCIT_C184955 NCIT_P399 "809210" @default.
- NCIT_C184955 normalizedInformationContent "100" @default.
- NCIT_C184955 referenceCount "1" @default.
- NCIT_C184955 hasExactSynonym "4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide" @default.
- NCIT_C184955 hasExactSynonym "BAY 73-4506 Monohydrate" @default.
- NCIT_C184955 hasExactSynonym "REGORAFENIB" @default.
- NCIT_C184955 hasExactSynonym "Regorafenib Hydrate" @default.
- NCIT_C184955 hasExactSynonym "Regorafenib Monohydrate" @default.
- NCIT_C184955 hasExactSynonym "Regorafenib" @default.
- NCIT_C184955 hasExactSynonym "Stivarga" @default.
- NCIT_C184955 inSubset NCIT_C116977 @default.
- NCIT_C184955 inSubset NCIT_C116978 @default.
- NCIT_C184955 inSubset NCIT_C128784 @default.
- NCIT_C184955 inSubset NCIT_C157711 @default.
- NCIT_C184955 inSubset NCIT_C157712 @default.
- NCIT_C184955 inSubset NCIT_C176424 @default.
- NCIT_C184955 inSubset NCIT_C63923 @default.
- NCIT_C184955 type Class @default.
- NCIT_C184955 isDefinedBy ncit.owl @default.
- NCIT_C184955 label "Regorafenib Hydrate" @default.
- NCIT_C184955 subClassOf NCIT_C1404 @default.
- NCIT_C184955 subClassOf NCIT_C163758 @default.
- NCIT_C184955 subClassOf NCIT_C163953 @default.
- NCIT_C184955 subClassOf NCIT_C1742 @default.
- NCIT_C184955 subClassOf NCIT_C184955 @default.
- NCIT_C184955 subClassOf NCIT_C1908 @default.
- NCIT_C184955 subClassOf NCIT_C1909 @default.
- NCIT_C184955 subClassOf NCIT_C1967 @default.
- NCIT_C184955 subClassOf NCIT_C274 @default.
- NCIT_C184955 subClassOf NCIT_C471 @default.
- NCIT_C184955 subClassOf NCIT_C93259 @default.