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- NCIT_C1851 IAO_0000115 "A dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy." @default.
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- NCIT_C1851 NCIT_NHC0 "C1851" @default.
- NCIT_C1851 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1851 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1851 NCIT_P107 "Bortezomib" @default.
- NCIT_C1851 NCIT_P108 "Bortezomib" @default.
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- NCIT_C1851 NCIT_P302 "Multiple Myeloma; Advanced Thyroid Cancer" @default.
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- NCIT_C1851 NCIT_P325 "A drug used to treat multiple myeloma. It is also used to treat mantle cell lymphoma in patients who have already received at least one other type of treatment and is being studied in the treatment of other types of cancer. Bortezomib blocks several molecular pathways in a cell and may cause cancer cells to die. It is a type of proteasome inhibitor and a type of dipeptidyl boronic acid." @default.
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- NCIT_C1851 hasExactSynonym "BORTEZOMIB" @default.
- NCIT_C1851 hasExactSynonym "Bortezomib" @default.
- NCIT_C1851 hasExactSynonym "LDP 341" @default.
- NCIT_C1851 hasExactSynonym "MLN341" @default.
- NCIT_C1851 hasExactSynonym "PS-341" @default.
- NCIT_C1851 hasExactSynonym "PS341" @default.
- NCIT_C1851 hasExactSynonym "Velcade" @default.
- NCIT_C1851 hasExactSynonym "[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid" @default.
- NCIT_C1851 hasExactSynonym "bortezomib" @default.
- NCIT_C1851 hasExactSynonym "velcade" @default.
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- NCIT_C1851 type Class @default.
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- NCIT_C1851 label "Bortezomib" @default.
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