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- NCIT_C185128 IAO_0000115 "A bispecific monoclonal antibody against both B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-CD3 bispecific antibody PF-07260437 targets and binds to both B7-H4 on the surface of tumor cells and CD3 on T-cells. This results in the cross-linking of tumor cells and T-cells, and induces a cytotoxic T-lymphocyte (CTL) response against B7-H4-expressing tumor cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and negatively regulates T-cell immune responses." @default.
- NCIT_C185128 NCIT_A7 NCIT_C106223 @default.
- NCIT_C185128 NCIT_NHC0 "C185128" @default.
- NCIT_C185128 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185128 NCIT_P107 "Anti-B7-H4/Anti-CD3 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 NCIT_P108 "Anti-B7-H4/Anti-CD3 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 NCIT_P208 "CL1773461" @default.
- NCIT_C185128 NCIT_P322 "CTRP" @default.
- NCIT_C185128 NCIT_P322 "GDC" @default.
- NCIT_C185128 NCIT_P399 "807027" @default.
- NCIT_C185128 NCIT_R124 NCIT_C17710 @default.
- NCIT_C185128 NCIT_R124 NCIT_C17828 @default.
- NCIT_C185128 NCIT_R124 NCIT_C18219 @default.
- NCIT_C185128 NCIT_R124 NCIT_C19986 @default.
- NCIT_C185128 NCIT_R124 NCIT_C40474 @default.
- NCIT_C185128 normalizedInformationContent "100" @default.
- NCIT_C185128 referenceCount "1" @default.
- NCIT_C185128 hasExactSynonym "Anti-B7-H4/Anti-CD3 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 hasExactSynonym "Anti-B7-H4/CD3 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 hasExactSynonym "Anti-CD3/Anti-B7-H4 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 hasExactSynonym "B7-H4 x CD3 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 hasExactSynonym "PF 07260437" @default.
- NCIT_C185128 hasExactSynonym "PF-07260437" @default.
- NCIT_C185128 hasExactSynonym "PF07260437" @default.
- NCIT_C185128 inSubset NCIT_C116977 @default.
- NCIT_C185128 inSubset NCIT_C116978 @default.
- NCIT_C185128 inSubset NCIT_C128784 @default.
- NCIT_C185128 inSubset NCIT_C157711 @default.
- NCIT_C185128 inSubset NCIT_C157712 @default.
- NCIT_C185128 inSubset NCIT_C176424 @default.
- NCIT_C185128 type Class @default.
- NCIT_C185128 isDefinedBy ncit.owl @default.
- NCIT_C185128 label "Anti-B7-H4/Anti-CD3 Bispecific Antibody PF-07260437" @default.
- NCIT_C185128 subClassOf NCIT_C112883 @default.
- NCIT_C185128 subClassOf NCIT_C129821 @default.
- NCIT_C185128 subClassOf NCIT_C129822 @default.
- NCIT_C185128 subClassOf NCIT_C1454 @default.
- NCIT_C185128 subClassOf NCIT_C163758 @default.
- NCIT_C185128 subClassOf NCIT_C185128 @default.
- NCIT_C185128 subClassOf NCIT_C1908 @default.
- NCIT_C185128 subClassOf NCIT_C1909 @default.
- NCIT_C185128 subClassOf NCIT_C199433 @default.
- NCIT_C185128 subClassOf NCIT_C199488 @default.
- NCIT_C185128 subClassOf NCIT_C201282 @default.
- NCIT_C185128 subClassOf NCIT_C20401 @default.
- NCIT_C185128 subClassOf NCIT_C274 @default.
- NCIT_C185128 subClassOf NCIT_C28227 @default.
- NCIT_C185128 subClassOf NCIT_C307 @default.
- NCIT_C185128 subClassOf NCIT_C308 @default.