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- NCIT_C185130 IAO_0000115 "A preparation of non-viral DNA plasmids encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), constructed with a p21 promoter and devoid of an antibiotic resistance gene, with potential immunostimulating and antineoplastic activities. Upon administration of DNA plasmid encoding human IL-12 (hIL-12) phIL12 via intratumoral injection and electroporation, or gene electrotransfer (GET), the plasmid is introduced into human cells resulting in the expression and highly-localized secretion of IL-12 in the tumor microenvironment (TME). This activates the immune system by promoting the activation of natural killer cells (NKs), inducing the secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-lymphocyte (CTL) responses against tumor cells. The switch from the constitutive promoter to the tumor-specific and genotoxic stress-inducible p21 promoter in the construction of phIL12 allows for high basal IL-12 expression in tumor cells. The lack of an antibiotic resistance gene improves the safety profile." @default.
- NCIT_C185130 NCIT_NHC0 "C185130" @default.
- NCIT_C185130 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185130 NCIT_P108 "DNA Plasmid Encoding Human IL-12 phIL12" @default.
- NCIT_C185130 NCIT_P208 "CL1773463" @default.
- NCIT_C185130 NCIT_P322 "GDC" @default.
- NCIT_C185130 NCIT_P399 "807069" @default.
- NCIT_C185130 normalizedInformationContent "100" @default.
- NCIT_C185130 referenceCount "1" @default.
- NCIT_C185130 hasExactSynonym "DNA Plasmid Encoding Human IL-12 phIL12" @default.
- NCIT_C185130 hasExactSynonym "DNA Plasmid Encoding hIL-12 phIL12" @default.
- NCIT_C185130 hasExactSynonym "IL-12 DNA Plasmid phIL12" @default.
- NCIT_C185130 hasExactSynonym "hIL-12-encoding DNA Plasmid phIL12" @default.
- NCIT_C185130 hasExactSynonym "p21-hIL-12-ORT" @default.
- NCIT_C185130 hasExactSynonym "phIL 12" @default.
- NCIT_C185130 hasExactSynonym "phIL-12" @default.
- NCIT_C185130 hasExactSynonym "phIL12" @default.
- NCIT_C185130 inSubset NCIT_C128784 @default.
- NCIT_C185130 inSubset NCIT_C157711 @default.
- NCIT_C185130 inSubset NCIT_C157712 @default.
- NCIT_C185130 inSubset NCIT_C176424 @default.
- NCIT_C185130 type Class @default.
- NCIT_C185130 isDefinedBy ncit.owl @default.
- NCIT_C185130 label "DNA Plasmid Encoding Human IL-12 phIL12" @default.
- NCIT_C185130 subClassOf NCIT_C129820 @default.
- NCIT_C185130 subClassOf NCIT_C185130 @default.
- NCIT_C185130 subClassOf NCIT_C1908 @default.
- NCIT_C185130 subClassOf NCIT_C1909 @default.
- NCIT_C185130 subClassOf NCIT_C1962 @default.
- NCIT_C185130 subClassOf NCIT_C274 @default.
- NCIT_C185130 subClassOf NCIT_C307 @default.
- NCIT_C185130 subClassOf NCIT_C308 @default.
- NCIT_C185130 subClassOf NCIT_C61199 @default.