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- NCIT_C185133 IAO_0000115 "A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the immunosuppressive receptor CD163 (scavenger receptor cysteine-rich type 1 protein M130), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD163 monoclonal antibody OR2805 targets and binds to CD163 expressed on immunosuppressive tumor-associated macrophages (TAMs) within the tumor microenvironment (TME), and prevents the binding of CD163 to its ligands. This inhibits CD163-mediated immunosuppression, including the secretion of immunosuppressive cytokines and the inhibition of T-cell activation. This enhances T-cell activation and proliferation and antitumor T-cell immune responses, which inhibits the proliferation of tumor cells. CD163, an immunosuppressive receptor highly expressed on TAMs, plays an important role in immunosuppression and the inhibition of anti-tumor T-cell immune responses." @default.
- NCIT_C185133 NCIT_A7 NCIT_C104064 @default.
- NCIT_C185133 NCIT_NHC0 "C185133" @default.
- NCIT_C185133 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185133 NCIT_P108 "Anti-CD163 Monoclonal Antibody OR2805" @default.
- NCIT_C185133 NCIT_P208 "CL1773464" @default.
- NCIT_C185133 NCIT_P322 "GDC" @default.
- NCIT_C185133 NCIT_P399 "807072" @default.
- NCIT_C185133 NCIT_R124 NCIT_C17710 @default.
- NCIT_C185133 NCIT_R124 NCIT_C17828 @default.
- NCIT_C185133 NCIT_R124 NCIT_C18219 @default.
- NCIT_C185133 NCIT_R124 NCIT_C19986 @default.
- NCIT_C185133 NCIT_R124 NCIT_C40474 @default.
- NCIT_C185133 normalizedInformationContent "100" @default.
- NCIT_C185133 referenceCount "1" @default.
- NCIT_C185133 hasExactSynonym "Anti-CD163 Monoclonal Antibody OR2805" @default.
- NCIT_C185133 hasExactSynonym "OR 2805" @default.
- NCIT_C185133 hasExactSynonym "OR-2805" @default.
- NCIT_C185133 hasExactSynonym "OR2805" @default.
- NCIT_C185133 inSubset NCIT_C128784 @default.
- NCIT_C185133 inSubset NCIT_C157711 @default.
- NCIT_C185133 inSubset NCIT_C157712 @default.
- NCIT_C185133 inSubset NCIT_C176424 @default.
- NCIT_C185133 type Class @default.
- NCIT_C185133 isDefinedBy ncit.owl @default.
- NCIT_C185133 label "Anti-CD163 Monoclonal Antibody OR2805" @default.
- NCIT_C185133 subClassOf NCIT_C129821 @default.
- NCIT_C185133 subClassOf NCIT_C129822 @default.
- NCIT_C185133 subClassOf NCIT_C185133 @default.
- NCIT_C185133 subClassOf NCIT_C1908 @default.
- NCIT_C185133 subClassOf NCIT_C1909 @default.
- NCIT_C185133 subClassOf NCIT_C20401 @default.
- NCIT_C185133 subClassOf NCIT_C274 @default.
- NCIT_C185133 subClassOf NCIT_C307 @default.
- NCIT_C185133 subClassOf NCIT_C308 @default.