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- NCIT_C185164 IAO_0000115 "A tri-specific, designed ankyrin repeat proteins (DARPin)-based agent targeting the tumor-associated protein fibroblast activation protein (FAP), CD40 receptor and human serum albumin (HSA), with potential immunostimulatory and antineoplastic activities. Upon administration, FAP/CD40-targeting DARPin MP0317 targets and binds to both FAP, localized predominantly on cancer-associated fibroblasts (CAFs) in the tumor stroma, and CD40, a cell surface stimulatory receptor expressed on various immune cells including B-lymphocytes, monocytes and dendritic cells (DCs). The simultaneous binding to FAP and CD40 results in local clustering of FAP-expressing tumor stromal cells and CD40-expressing immune cells. Activation of CD40 induces proliferation and activation of B-lymphocytes, shifts the induction of suppressive macrophages towards immunostimulatory macrophages, activates monocyte-derived DCs (moDCs), and leads to the secretion of inflammatory cytokines, which activates the immune system to induce the proliferation and activation of cytotoxic T-lymphocytes (CTLs) against tumor cells. CD40, a member of the tumor necrosis factor receptor superfamily (TNFRSF), plays a key role in the activation of the immune system. FAP is abundantly expressed by CAFs in the majority of solid tumors. HSA binding prolongs the half-life of MP0317. Compared to antibodies, DARPins are small in size, have favorable pharmacokinetics and allow for both high affinity binding and efficacy." @default.
- NCIT_C185164 NCIT_A7 NCIT_C17281 @default.
- NCIT_C185164 NCIT_A7 NCIT_C17799 @default.
- NCIT_C185164 NCIT_NHC0 "C185164" @default.
- NCIT_C185164 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185164 NCIT_P108 "FAP/CD40-targeting DARPin MP0317" @default.
- NCIT_C185164 NCIT_P208 "CL1773495" @default.
- NCIT_C185164 NCIT_P322 "GDC" @default.
- NCIT_C185164 NCIT_P399 "807110" @default.
- NCIT_C185164 normalizedInformationContent "100" @default.
- NCIT_C185164 referenceCount "1" @default.
- NCIT_C185164 hasExactSynonym "Anti-CD40/Anti-FAP DARPin Agent MP0317" @default.
- NCIT_C185164 hasExactSynonym "FAP x CD40-targeting DARPin MP0317" @default.
- NCIT_C185164 hasExactSynonym "FAP/CD40-targeting DARPin MP0317" @default.
- NCIT_C185164 hasExactSynonym "FAP/CD40-targeting Designed Ankyrin Repeat Protein MP0317" @default.
- NCIT_C185164 hasExactSynonym "MP 0317" @default.
- NCIT_C185164 hasExactSynonym "MP-0317" @default.
- NCIT_C185164 hasExactSynonym "MP0317" @default.
- NCIT_C185164 inSubset NCIT_C128784 @default.
- NCIT_C185164 inSubset NCIT_C157711 @default.
- NCIT_C185164 inSubset NCIT_C157712 @default.
- NCIT_C185164 inSubset NCIT_C176424 @default.
- NCIT_C185164 type Class @default.
- NCIT_C185164 isDefinedBy ncit.owl @default.
- NCIT_C185164 label "FAP/CD40-targeting DARPin MP0317" @default.
- NCIT_C185164 subClassOf NCIT_C129820 @default.
- NCIT_C185164 subClassOf NCIT_C185164 @default.
- NCIT_C185164 subClassOf NCIT_C1908 @default.
- NCIT_C185164 subClassOf NCIT_C1909 @default.
- NCIT_C185164 subClassOf NCIT_C191767 @default.
- NCIT_C185164 subClassOf NCIT_C274 @default.
- NCIT_C185164 subClassOf NCIT_C308 @default.