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- NCIT_C185284 IAO_0000115 "An orally bioavailable, small molecule inhibitor of human vascular endothelial growth factor receptor 3 (VEGFR3; VEGFR-3; Flt-4), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, VEGFR3 inhibitor EVT801 specifically targets, binds to and inhibits VEGFR3 tyrosine kinase, which may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. EVT801 may also decrease the level of immune suppressive myeloid derived suppressor cells (MDSCs) in the blood, thereby activating anti-tumor immune responses. VEGFR3 plays a critical role in the embryonic vascular system development but is restricted postnatally to endothelial cells of lymphatic vessels and found to be expressed in many solid and hematologic malignancies." @default.
- NCIT_C185284 NCIT_A7 NCIT_C26203 @default.
- NCIT_C185284 NCIT_NHC0 "C185284" @default.
- NCIT_C185284 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185284 NCIT_P108 "VEGFR3 Inhibitor EVT801" @default.
- NCIT_C185284 NCIT_P208 "CL1773390" @default.
- NCIT_C185284 NCIT_P322 "GDC" @default.
- NCIT_C185284 NCIT_P399 "808177" @default.
- NCIT_C185284 normalizedInformationContent "100" @default.
- NCIT_C185284 referenceCount "1" @default.
- NCIT_C185284 hasExactSynonym "EVT 801" @default.
- NCIT_C185284 hasExactSynonym "EVT-801" @default.
- NCIT_C185284 hasExactSynonym "EVT801" @default.
- NCIT_C185284 hasExactSynonym "VEGFR3 Inhibitor EVT801" @default.
- NCIT_C185284 inSubset NCIT_C128784 @default.
- NCIT_C185284 inSubset NCIT_C157711 @default.
- NCIT_C185284 inSubset NCIT_C157712 @default.
- NCIT_C185284 inSubset NCIT_C176424 @default.
- NCIT_C185284 type Class @default.
- NCIT_C185284 isDefinedBy ncit.owl @default.
- NCIT_C185284 label "VEGFR3 Inhibitor EVT801" @default.
- NCIT_C185284 subClassOf NCIT_C129824 @default.
- NCIT_C185284 subClassOf NCIT_C129825 @default.
- NCIT_C185284 subClassOf NCIT_C1404 @default.
- NCIT_C185284 subClassOf NCIT_C185284 @default.
- NCIT_C185284 subClassOf NCIT_C1908 @default.
- NCIT_C185284 subClassOf NCIT_C1909 @default.
- NCIT_C185284 subClassOf NCIT_C1967 @default.
- NCIT_C185284 subClassOf NCIT_C2189 @default.
- NCIT_C185284 subClassOf NCIT_C274 @default.
- NCIT_C185284 subClassOf NCIT_C471 @default.