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- NCIT_C185290 IAO_0000115 "A hydrogel carrier-based, sustained-release (SR) formulation containing a variant of the endogenous cytokine interleukin-2 (IL-2), with potential immunostimulating and antineoplastic activities. Upon intravenous administration of TransCon IL-2 beta/gamma (IL-2b/g), the IL-2b/g variant is slowly released over an extended period of time and selectively binds to the IL-2 receptor b/g subunit (IL2Rb/g). The binding of IL-2b/g variant to IL2Rb/g activates IL2Rb/g-mediated signaling, which activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). The activation of the immune responses against tumor cells causes tumor cell destruction. IL2Rb/g plays a key role in the proliferation and activation of effector T-cells. IL-2b/g minimally binds to the IL2Ralpha subunit (IL2Ra). Signaling through IL2Ra activates CD4-positive regulatory, immunosuppressive T-cells (Tregs), which would suppress tumor cell killing." @default.
- NCIT_C185290 NCIT_A7 NCIT_C26266 @default.
- NCIT_C185290 NCIT_A7 NCIT_C26267 @default.
- NCIT_C185290 NCIT_NHC0 "C185290" @default.
- NCIT_C185290 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185290 NCIT_P108 "TransCon IL-2 Beta/Gamma" @default.
- NCIT_C185290 NCIT_P208 "CL1773396" @default.
- NCIT_C185290 NCIT_P322 "GDC" @default.
- NCIT_C185290 NCIT_P399 "808170" @default.
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- NCIT_C185290 NCIT_R125 NCIT_C28498 @default.
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- NCIT_C185290 NCIT_R125 NCIT_C40912 @default.
- NCIT_C185290 NCIT_R146 NCIT_C104679 @default.
- NCIT_C185290 NCIT_R146 NCIT_C21176 @default.
- NCIT_C185290 NCIT_R146 NCIT_C26548 @default.
- NCIT_C185290 normalizedInformationContent "100" @default.
- NCIT_C185290 referenceCount "1" @default.
- NCIT_C185290 hasExactSynonym "TransCon IL-2 Beta/Gamma" @default.
- NCIT_C185290 hasExactSynonym "TransCon IL-2b/g" @default.
- NCIT_C185290 hasExactSynonym "TransCon Interleukin-2 Beta/Gamma" @default.
- NCIT_C185290 inSubset NCIT_C128784 @default.
- NCIT_C185290 inSubset NCIT_C157711 @default.
- NCIT_C185290 inSubset NCIT_C157712 @default.
- NCIT_C185290 inSubset NCIT_C176424 @default.
- NCIT_C185290 type Class @default.
- NCIT_C185290 isDefinedBy ncit.owl @default.
- NCIT_C185290 label "TransCon IL-2 Beta/Gamma" @default.
- NCIT_C185290 subClassOf NCIT_C1283 @default.
- NCIT_C185290 subClassOf NCIT_C185290 @default.
- NCIT_C185290 subClassOf NCIT_C1908 @default.
- NCIT_C185290 subClassOf NCIT_C1909 @default.
- NCIT_C185290 subClassOf NCIT_C307 @default.
- NCIT_C185290 subClassOf NCIT_C308 @default.
- NCIT_C185290 subClassOf NCIT_C587 @default.
- NCIT_C185290 subClassOf NCIT_C593 @default.