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- NCIT_C18537 IAO_0000115 "MYC Family Genes encode MYC Family Proteins, class III bHLH leucine zipper transcription factors having cellular proliferative and apoptotic roles. Dimerization via leucine zippers of MYC proteins with bHLH/lz proteins, such as MAX, is required for efficient DNA binding. Leucine zippers are present in many gene regulatory proteins, including CREB proteins, Jun/AP1 transcription factors, and FOS-type proteins, as well as MYC proteins. The periodically repeated leucine side chains extending from one alpha helix interdigitate with leucine residues of another alpha helix, facilitating coiled-coil dimerization; like charge repulsion in this region perturbs homodimer formation; heterodimers are promoted by opposing charge attractions. c-MYC transcription factor binds to CAC(GA)TG DNA sites. MYC sequences have been highly conserved throughout evolution, from Drosophila to vertebrates. (NCI)" @default.
- NCIT_C18537 NCIT_NHC0 "C18537" @default.
- NCIT_C18537 NCIT_P106 "Gene or Genome" @default.
- NCIT_C18537 NCIT_P107 "MYC Family Gene" @default.
- NCIT_C18537 NCIT_P108 "MYC Family Gene" @default.
- NCIT_C18537 NCIT_P207 "C0026902" @default.
- NCIT_C18537 NCIT_P322 "CTRP" @default.
- NCIT_C18537 NCIT_P366 "MYC_Family_Gene" @default.
- NCIT_C18537 NCIT_P96 "MYC Family Protein" @default.
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- NCIT_C18537 normalizedInformationContent "62.929871480845904" @default.
- NCIT_C18537 referenceCount "271" @default.
- NCIT_C18537 hasExactSynonym "MYC Family Gene" @default.
- NCIT_C18537 hasExactSynonym "MYC Gene" @default.
- NCIT_C18537 inSubset NCIT_C116977 @default.
- NCIT_C18537 inSubset NCIT_C142799 @default.
- NCIT_C18537 inSubset NCIT_C142800 @default.
- NCIT_C18537 type Class @default.
- NCIT_C18537 isDefinedBy ncit.owl @default.
- NCIT_C18537 label "MYC Family Gene" @default.
- NCIT_C18537 subClassOf B2d250973175ede920f6314af1dfa0f20 @default.
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- NCIT_C18537 subClassOf NCIT_C16612 @default.
- NCIT_C18537 subClassOf NCIT_C18537 @default.
- NCIT_C18537 subClassOf NCIT_C20420 @default.
- NCIT_C18537 subClassOf NCIT_C54362 @default.