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- NCIT_C185396 IAO_0000115 "An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, BET inhibitor TQB3617 targets and binds to the acetyl-lysine binding site in the bromodomains (BRDs), thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and suppresses the expression of certain oncogenes, resulting in the inhibition of tumor cell growth. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role in the modulation of gene expression during cellular growth and development." @default.
- NCIT_C185396 NCIT_A7 NCIT_C106463 @default.
- NCIT_C185396 NCIT_A7 NCIT_C21376 @default.
- NCIT_C185396 NCIT_A7 NCIT_C92704 @default.
- NCIT_C185396 NCIT_A7 NCIT_C97399 @default.
- NCIT_C185396 NCIT_NHC0 "C185396" @default.
- NCIT_C185396 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185396 NCIT_P108 "BET Inhibitor TQB3617" @default.
- NCIT_C185396 NCIT_P208 "CL1773811" @default.
- NCIT_C185396 NCIT_P322 "GDC" @default.
- NCIT_C185396 NCIT_P399 "808275" @default.
- NCIT_C185396 normalizedInformationContent "100" @default.
- NCIT_C185396 referenceCount "1" @default.
- NCIT_C185396 hasExactSynonym "BET Inhibitor TQB3617" @default.
- NCIT_C185396 hasExactSynonym "TQB 3617" @default.
- NCIT_C185396 hasExactSynonym "TQB-3617" @default.
- NCIT_C185396 hasExactSynonym "TQB3617" @default.
- NCIT_C185396 inSubset NCIT_C128784 @default.
- NCIT_C185396 inSubset NCIT_C157711 @default.
- NCIT_C185396 inSubset NCIT_C157712 @default.
- NCIT_C185396 inSubset NCIT_C176424 @default.
- NCIT_C185396 type Class @default.
- NCIT_C185396 isDefinedBy ncit.owl @default.
- NCIT_C185396 label "BET Inhibitor TQB3617" @default.
- NCIT_C185396 subClassOf NCIT_C128462 @default.
- NCIT_C185396 subClassOf NCIT_C129824 @default.
- NCIT_C185396 subClassOf NCIT_C185396 @default.
- NCIT_C185396 subClassOf NCIT_C1908 @default.
- NCIT_C185396 subClassOf NCIT_C1909 @default.
- NCIT_C185396 subClassOf NCIT_C2189 @default.
- NCIT_C185396 subClassOf NCIT_C274 @default.