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- NCIT_C185399 IAO_0000115 "A synthetic tumor targeted immune cell agonist composed of two bicyclic peptides targeting CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9) linked to a bicyclic peptide targeting the cell adhesion molecule nectin-4 (PVRL4); with potential immunostimulating and antineoplastic activities. Upon administration, CD137/nectin-4 bispecific-targeting agent BT7480 simultaneously targets and binds to CD137, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes, and nectin-4 expressed on tumor cells. The simultaneous binding to nectin-4 and CD137 allows for conditional stimulation of CD137 signaling within the tumor microenvironment (TME) only upon binding to nectin-4 on tumor cells. CD137 activation results in T-cell stimulation and enhances T-lymphocyte-mediated anti-tumor immune response against nectin-4-expressing tumor cells. Nectin-4, a tumor associated antigen (TAA) belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C185399 NCIT_A7 NCIT_C105113 @default.
- NCIT_C185399 NCIT_A7 NCIT_C134483 @default.
- NCIT_C185399 NCIT_NHC0 "C185399" @default.
- NCIT_C185399 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185399 NCIT_P107 "CD137/Nectin-4 Bispecific-targeting Agent BT7480" @default.
- NCIT_C185399 NCIT_P108 "CD137/Nectin-4 Bispecific-targeting Agent BT7480" @default.
- NCIT_C185399 NCIT_P208 "CL1773814" @default.
- NCIT_C185399 NCIT_P322 "CTRP" @default.
- NCIT_C185399 NCIT_P322 "GDC" @default.
- NCIT_C185399 NCIT_P399 "808289" @default.
- NCIT_C185399 normalizedInformationContent "100" @default.
- NCIT_C185399 referenceCount "1" @default.
- NCIT_C185399 hasExactSynonym "4-1BB/Nectin-4 Bispecific-targeting Agent BT7480" @default.
- NCIT_C185399 hasExactSynonym "BT 7480" @default.
- NCIT_C185399 hasExactSynonym "BT-7480" @default.
- NCIT_C185399 hasExactSynonym "BT7480" @default.
- NCIT_C185399 hasExactSynonym "CD137/Nectin-4 Bispecific TICA BT7480" @default.
- NCIT_C185399 hasExactSynonym "CD137/Nectin-4 Bispecific Tumor-targeted Immune Cell Agonist BT7480" @default.
- NCIT_C185399 hasExactSynonym "CD137/Nectin-4 Bispecific-targeting Agent BT7480" @default.
- NCIT_C185399 hasExactSynonym "Nectin-4/CD137 Bispecific-targeting Agent BT7480" @default.
- NCIT_C185399 inSubset NCIT_C116977 @default.
- NCIT_C185399 inSubset NCIT_C116978 @default.
- NCIT_C185399 inSubset NCIT_C128784 @default.
- NCIT_C185399 inSubset NCIT_C157711 @default.
- NCIT_C185399 inSubset NCIT_C157712 @default.
- NCIT_C185399 inSubset NCIT_C176424 @default.
- NCIT_C185399 type Class @default.
- NCIT_C185399 isDefinedBy ncit.owl @default.
- NCIT_C185399 label "CD137/Nectin-4 Bispecific-targeting Agent BT7480" @default.
- NCIT_C185399 subClassOf NCIT_C129820 @default.
- NCIT_C185399 subClassOf NCIT_C185399 @default.
- NCIT_C185399 subClassOf NCIT_C1908 @default.
- NCIT_C185399 subClassOf NCIT_C1909 @default.
- NCIT_C185399 subClassOf NCIT_C192997 @default.
- NCIT_C185399 subClassOf NCIT_C274 @default.
- NCIT_C185399 subClassOf NCIT_C308 @default.