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- NCIT_C185407 IAO_0000115 "An engineered tri-specific natural killer (NK) cell engager (NKCE) containing specific antibodies targeting the tumor-associated antigen cluster of differentiation 123 (CD123), and the NK activating receptors natural cytotoxicity triggering receptor (NKp46; activating natural killer receptor p46) and CD16, with potential immunostimulating and antineoplastic activities. Upon administration of NKp46/CD16-based CD123-targeted NK cell engager SAR443579, the NKCE targets and binds to CD123 expressed on tumor cells and simultaneously binds, via the activating receptors NKp46 and CD16, to NK cells, thereby bringing CD123-expressing tumor cells and NK cells together. This stimulates the NK cells and results in the selective NK cell-mediated tumor cell lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness." @default.
- NCIT_C185407 NCIT_A7 NCIT_C39275 @default.
- NCIT_C185407 NCIT_NHC0 "C185407" @default.
- NCIT_C185407 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185407 NCIT_P107 "NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579" @default.
- NCIT_C185407 NCIT_P108 "NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579" @default.
- NCIT_C185407 NCIT_P208 "CL1773834" @default.
- NCIT_C185407 NCIT_P322 "CTRP" @default.
- NCIT_C185407 NCIT_P322 "GDC" @default.
- NCIT_C185407 NCIT_P399 "808229" @default.
- NCIT_C185407 normalizedInformationContent "100" @default.
- NCIT_C185407 referenceCount "1" @default.
- NCIT_C185407 hasExactSynonym "IPH 6101" @default.
- NCIT_C185407 hasExactSynonym "IPH-6101" @default.
- NCIT_C185407 hasExactSynonym "IPH6101" @default.
- NCIT_C185407 hasExactSynonym "NKCE SAR443579" @default.
- NCIT_C185407 hasExactSynonym "NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579" @default.
- NCIT_C185407 hasExactSynonym "NKp46/CD16-based NKCE IPH6101" @default.
- NCIT_C185407 hasExactSynonym "SAR 443579" @default.
- NCIT_C185407 hasExactSynonym "SAR-443579" @default.
- NCIT_C185407 hasExactSynonym "SAR443579" @default.
- NCIT_C185407 inSubset NCIT_C116977 @default.
- NCIT_C185407 inSubset NCIT_C116978 @default.
- NCIT_C185407 inSubset NCIT_C128784 @default.
- NCIT_C185407 inSubset NCIT_C157711 @default.
- NCIT_C185407 inSubset NCIT_C157712 @default.
- NCIT_C185407 inSubset NCIT_C176424 @default.
- NCIT_C185407 type Class @default.
- NCIT_C185407 isDefinedBy ncit.owl @default.
- NCIT_C185407 label "NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579" @default.
- NCIT_C185407 subClassOf NCIT_C129820 @default.
- NCIT_C185407 subClassOf NCIT_C185407 @default.
- NCIT_C185407 subClassOf NCIT_C1908 @default.
- NCIT_C185407 subClassOf NCIT_C1909 @default.
- NCIT_C185407 subClassOf NCIT_C274 @default.
- NCIT_C185407 subClassOf NCIT_C308 @default.