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- NCIT_C185419 IAO_0000115 "An orally available inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor NKT2152 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors." @default.
- NCIT_C185419 NCIT_A7 NCIT_C104306 @default.
- NCIT_C185419 NCIT_NHC0 "C185419" @default.
- NCIT_C185419 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185419 NCIT_P107 "HIF2-alpha Inhibitor NKT2152" @default.
- NCIT_C185419 NCIT_P108 "HIF2-alpha Inhibitor NKT2152" @default.
- NCIT_C185419 NCIT_P208 "CL1773733" @default.
- NCIT_C185419 NCIT_P322 "CTRP" @default.
- NCIT_C185419 NCIT_P322 "GDC" @default.
- NCIT_C185419 NCIT_P399 "808224" @default.
- NCIT_C185419 normalizedInformationContent "100" @default.
- NCIT_C185419 referenceCount "1" @default.
- NCIT_C185419 hasExactSynonym "HIF-2alpha Inhibitor NKT 2152" @default.
- NCIT_C185419 hasExactSynonym "HIF2-alpha Inhibitor NKT2152" @default.
- NCIT_C185419 hasExactSynonym "HIF2a Inhibitor NKT2152" @default.
- NCIT_C185419 hasExactSynonym "NKT 2152" @default.
- NCIT_C185419 hasExactSynonym "NKT-2152" @default.
- NCIT_C185419 hasExactSynonym "NKT2152" @default.
- NCIT_C185419 inSubset NCIT_C116977 @default.
- NCIT_C185419 inSubset NCIT_C116978 @default.
- NCIT_C185419 inSubset NCIT_C128784 @default.
- NCIT_C185419 inSubset NCIT_C157711 @default.
- NCIT_C185419 inSubset NCIT_C157712 @default.
- NCIT_C185419 inSubset NCIT_C176424 @default.
- NCIT_C185419 type Class @default.
- NCIT_C185419 isDefinedBy ncit.owl @default.
- NCIT_C185419 label "HIF2-alpha Inhibitor NKT2152" @default.
- NCIT_C185419 subClassOf NCIT_C129824 @default.
- NCIT_C185419 subClassOf NCIT_C185419 @default.
- NCIT_C185419 subClassOf NCIT_C1908 @default.
- NCIT_C185419 subClassOf NCIT_C1909 @default.
- NCIT_C185419 subClassOf NCIT_C192728 @default.
- NCIT_C185419 subClassOf NCIT_C2189 @default.
- NCIT_C185419 subClassOf NCIT_C274 @default.