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- NCIT_C185421 IAO_0000115 "An orally bioavailable selective inhibitor of the gamma isoform of phosphoinositide-3 kinase (PI3Kg), with potential immunomodulating and antineoplastic activities. Upon oral administration of PI3Kg inhibitor ZX-4081, this agent targets and inhibits the PI3Kg isoform and prevents the activation of the PI3Kg-AKT-mediated signaling pathway. As PI3Kg plays an important role in immune suppression and promotes immunosuppressive myeloid cell polarization during tumor growth and metastasis, the inhibition of PI3Kg may abrogate the immune-suppressive nature in the tumor microenvironment (TME) and impair PI3Kg-AKT-mediated macrophage polarization. This may promote anti-tumor immunity, may increase CD8-positive T-cell activation and M1-like macrophages and may lead to a reduction in cellular proliferation in PI3Kg-expressing tumor cells. By selectively targeting this isoform, PI3K signaling in normal, non-neoplastic cells is minimally impacted or not affected at all, which minimizes the side effect profile for this agent. PI3Kg is highly expressed in leukocytes and plays a critical role in activation of myeloid cells at sites of inflammation and tumorigenesis, T-cell recruitment into the TME, chemokine-mediated chemotaxis and growth factor signaling." @default.
- NCIT_C185421 NCIT_A7 NCIT_C30171 @default.
- NCIT_C185421 NCIT_NHC0 "C185421" @default.
- NCIT_C185421 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185421 NCIT_P107 "PI3K-gamma Inhibitor ZX-4081" @default.
- NCIT_C185421 NCIT_P108 "PI3K-gamma Inhibitor ZX-4081" @default.
- NCIT_C185421 NCIT_P208 "CL1773731" @default.
- NCIT_C185421 NCIT_P322 "CTRP" @default.
- NCIT_C185421 NCIT_P322 "GDC" @default.
- NCIT_C185421 NCIT_P399 "808226" @default.
- NCIT_C185421 normalizedInformationContent "100" @default.
- NCIT_C185421 referenceCount "1" @default.
- NCIT_C185421 hasExactSynonym "PI3K-g Inhibitor ZX-4081" @default.
- NCIT_C185421 hasExactSynonym "PI3K-gamma Inhibitor ZX-4081" @default.
- NCIT_C185421 hasExactSynonym "PI3Kg Inhibitor ZX-4081" @default.
- NCIT_C185421 hasExactSynonym "PI3Kgamma Inhibitor ZX-4081" @default.
- NCIT_C185421 hasExactSynonym "ZX 4081" @default.
- NCIT_C185421 hasExactSynonym "ZX-4081" @default.
- NCIT_C185421 hasExactSynonym "ZX4081" @default.
- NCIT_C185421 inSubset NCIT_C116977 @default.
- NCIT_C185421 inSubset NCIT_C116978 @default.
- NCIT_C185421 inSubset NCIT_C128784 @default.
- NCIT_C185421 inSubset NCIT_C157711 @default.
- NCIT_C185421 inSubset NCIT_C157712 @default.
- NCIT_C185421 inSubset NCIT_C176424 @default.
- NCIT_C185421 type Class @default.
- NCIT_C185421 isDefinedBy ncit.owl @default.
- NCIT_C185421 label "PI3K-gamma Inhibitor ZX-4081" @default.
- NCIT_C185421 subClassOf NCIT_C129824 @default.
- NCIT_C185421 subClassOf NCIT_C129825 @default.
- NCIT_C185421 subClassOf NCIT_C1404 @default.
- NCIT_C185421 subClassOf NCIT_C163758 @default.
- NCIT_C185421 subClassOf NCIT_C1742 @default.
- NCIT_C185421 subClassOf NCIT_C185421 @default.
- NCIT_C185421 subClassOf NCIT_C1908 @default.
- NCIT_C185421 subClassOf NCIT_C1909 @default.
- NCIT_C185421 subClassOf NCIT_C2152 @default.
- NCIT_C185421 subClassOf NCIT_C2189 @default.
- NCIT_C185421 subClassOf NCIT_C274 @default.
- NCIT_C185421 subClassOf NCIT_C471 @default.