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- NCIT_C185422 IAO_0000115 "An orally available selective inhibitor of the receptor tyrosine kinase c-ros oncogene 1 (ROS1), with potential antineoplastic activity. Upon oral administration, zidesamtinib targets, binds to and inhibits wild-type, point mutants and fusion proteins of ROS1. This inhibits proliferation of ROS-1-driven tumor cells, including in tumor cells harboring certain ROS1 resistance mutations, such as the solvent front mutation G2032R and the S1986Y/F, L2026M, and D2033N resistance mutations. Inhibition of ROS1 leads to the disruption of downstream signaling pathways and the inhibition of cell growth of tumors in which ROS1 overexpressed, rearranged or mutated. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NVL-520 is able to penetrate the blood-brain barrier (BBB)." @default.
- NCIT_C185422 NCIT_A7 NCIT_C17691 @default.
- NCIT_C185422 NCIT_NHC0 "C185422" @default.
- NCIT_C185422 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185422 NCIT_P107 "Zidesamtinib" @default.
- NCIT_C185422 NCIT_P108 "Zidesamtinib" @default.
- NCIT_C185422 NCIT_P208 "CL1773732" @default.
- NCIT_C185422 NCIT_P210 "2739829-00-4" @default.
- NCIT_C185422 NCIT_P319 "MX5KQV5XHC" @default.
- NCIT_C185422 NCIT_P322 "CTRP" @default.
- NCIT_C185422 NCIT_P322 "FDA" @default.
- NCIT_C185422 NCIT_P322 "GDC" @default.
- NCIT_C185422 NCIT_P399 "808232" @default.
- NCIT_C185422 normalizedInformationContent "100" @default.
- NCIT_C185422 referenceCount "1" @default.
- NCIT_C185422 hasExactSynonym "NUV 520" @default.
- NCIT_C185422 hasExactSynonym "NUV-520" @default.
- NCIT_C185422 hasExactSynonym "NUV520" @default.
- NCIT_C185422 hasExactSynonym "NVL 520" @default.
- NCIT_C185422 hasExactSynonym "NVL-520" @default.
- NCIT_C185422 hasExactSynonym "NVL520" @default.
- NCIT_C185422 hasExactSynonym "ROS1 Inhibitor NUV-520" @default.
- NCIT_C185422 hasExactSynonym "ROS1 Inhibitor NVL-520" @default.
- NCIT_C185422 hasExactSynonym "SIM18031A" @default.
- NCIT_C185422 hasExactSynonym "ZIDESAMTINIB" @default.
- NCIT_C185422 hasExactSynonym "Zidesamtinib" @default.
- NCIT_C185422 inSubset NCIT_C116977 @default.
- NCIT_C185422 inSubset NCIT_C116978 @default.
- NCIT_C185422 inSubset NCIT_C128784 @default.
- NCIT_C185422 inSubset NCIT_C157711 @default.
- NCIT_C185422 inSubset NCIT_C157712 @default.
- NCIT_C185422 inSubset NCIT_C176424 @default.
- NCIT_C185422 inSubset NCIT_C63923 @default.
- NCIT_C185422 type Class @default.
- NCIT_C185422 isDefinedBy ncit.owl @default.
- NCIT_C185422 label "Zidesamtinib" @default.
- NCIT_C185422 subClassOf NCIT_C129824 @default.
- NCIT_C185422 subClassOf NCIT_C129825 @default.
- NCIT_C185422 subClassOf NCIT_C185422 @default.
- NCIT_C185422 subClassOf NCIT_C1908 @default.
- NCIT_C185422 subClassOf NCIT_C1909 @default.
- NCIT_C185422 subClassOf NCIT_C2189 @default.
- NCIT_C185422 subClassOf NCIT_C274 @default.
- NCIT_C185422 subClassOf NCIT_C471 @default.