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- NCIT_C185426 IAO_0000115 "A recombinant bifunctional fusion protein composed of a humanized immunoglobulin (Ig) G1 anti-programmed death ligand 1 (PD-L1) monoclonal antibody fused to the extracellular domain (ECD) of the human transforming growth factor beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating activities. Upon administration of anti-PD-L1/TGFbetaRII fusion protein BJ-005, the TGFbetaRII moiety targets, binds to and neutralizes TGFbeta while the antibody moiety simultaneously targets, binds to, and inhibits the activity of PD-L1 on the tumor cell. This prevents both TGFbeta- and PD-L1-mediated immuno-suppressive pathways signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This restores and enhances anti-tumor responses and inhibits tumor cell proliferation in susceptible tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers and and play key roles in tumor immune suppression; their overexpression is associated with increased evasion of immune surveillance and contributes to poor prognosis." @default.
- NCIT_C185426 NCIT_A7 NCIT_C20457 @default.
- NCIT_C185426 NCIT_A7 NCIT_C20458 @default.
- NCIT_C185426 NCIT_A7 NCIT_C20459 @default.
- NCIT_C185426 NCIT_A7 NCIT_C96024 @default.
- NCIT_C185426 NCIT_NHC0 "C185426" @default.
- NCIT_C185426 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185426 NCIT_P107 "Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005" @default.
- NCIT_C185426 NCIT_P108 "Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005" @default.
- NCIT_C185426 NCIT_P208 "CL1773736" @default.
- NCIT_C185426 NCIT_P322 "CTRP" @default.
- NCIT_C185426 NCIT_P322 "GDC" @default.
- NCIT_C185426 NCIT_P399 "808236" @default.
- NCIT_C185426 normalizedInformationContent "100" @default.
- NCIT_C185426 referenceCount "1" @default.
- NCIT_C185426 hasExactSynonym "Anti-PD-L1/TGF-beta Receptor II Bispecific Fusion Protein BJ-005" @default.
- NCIT_C185426 hasExactSynonym "Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005" @default.
- NCIT_C185426 hasExactSynonym "BJ 005" @default.
- NCIT_C185426 hasExactSynonym "BJ-005" @default.
- NCIT_C185426 hasExactSynonym "BJ005" @default.
- NCIT_C185426 hasExactSynonym "Bispecific Fusion Protein BJ-005" @default.
- NCIT_C185426 inSubset NCIT_C116977 @default.
- NCIT_C185426 inSubset NCIT_C116978 @default.
- NCIT_C185426 inSubset NCIT_C128784 @default.
- NCIT_C185426 inSubset NCIT_C157711 @default.
- NCIT_C185426 inSubset NCIT_C157712 @default.
- NCIT_C185426 inSubset NCIT_C176424 @default.
- NCIT_C185426 type Class @default.
- NCIT_C185426 isDefinedBy ncit.owl @default.
- NCIT_C185426 label "Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005" @default.
- NCIT_C185426 subClassOf NCIT_C129820 @default.
- NCIT_C185426 subClassOf NCIT_C185426 @default.
- NCIT_C185426 subClassOf NCIT_C1908 @default.
- NCIT_C185426 subClassOf NCIT_C1909 @default.
- NCIT_C185426 subClassOf NCIT_C274 @default.
- NCIT_C185426 subClassOf NCIT_C308 @default.