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- NCIT_C185560 IAO_0000115 "An orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73; 5'-ecto-nucleotidase; 5'-NT; ecto-5'-nucleotidase), with potential immunomodulating and antineoplastic activities. Upon oral administration, CD73 inhibitor ORIC-533 targets and binds to CD73, leading to clustering of and internalization of CD73. This prevents CD73-mediated conversion of adenosine monophosphate (AMP) to adenosine and decreases the amount of free adenosine in the tumor microenvironment (TME). This prevents adenosine-mediated lymphocyte suppression and increases the activity of CD8-positive effector cells and natural killer (NK) cells. This also activates macrophages and reduces the activity of myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes (Tregs). By abrogating the inhibitory effect on the immune system and enhancing the cytotoxic T-cell-mediated immune response against tumor cells, tumor cell growth decreases. In addition, clustering and internalization of CD73 decreases the migration of cancer cells and prevents metastasis. CD73, a plasma membrane protein belonging to the 5'-nucleotidase (NTase) family, catalyzes the conversion of extracellular nucleotides, such as AMP, to membrane-permeable nucleosides, such as adenosine. It is upregulated in a variety of cancer cell types and plays a key role in adenosine-mediated immunosuppression within the TME." @default.
- NCIT_C185560 NCIT_A7 NCIT_C114927 @default.
- NCIT_C185560 NCIT_NHC0 "C185560" @default.
- NCIT_C185560 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185560 NCIT_P107 "CD73 Inhibitor ORIC-533" @default.
- NCIT_C185560 NCIT_P108 "CD73 Inhibitor ORIC-533" @default.
- NCIT_C185560 NCIT_P208 "CL1773916" @default.
- NCIT_C185560 NCIT_P322 "CTRP" @default.
- NCIT_C185560 NCIT_P322 "GDC" @default.
- NCIT_C185560 NCIT_P399 "809242" @default.
- NCIT_C185560 normalizedInformationContent "100" @default.
- NCIT_C185560 referenceCount "1" @default.
- NCIT_C185560 hasExactSynonym "CD73 Inhibitor ORIC-533" @default.
- NCIT_C185560 hasExactSynonym "ORIC 533" @default.
- NCIT_C185560 hasExactSynonym "ORIC-533" @default.
- NCIT_C185560 hasExactSynonym "ORIC533" @default.
- NCIT_C185560 inSubset NCIT_C116977 @default.
- NCIT_C185560 inSubset NCIT_C116978 @default.
- NCIT_C185560 inSubset NCIT_C128784 @default.
- NCIT_C185560 inSubset NCIT_C157711 @default.
- NCIT_C185560 inSubset NCIT_C157712 @default.
- NCIT_C185560 inSubset NCIT_C176424 @default.
- NCIT_C185560 type Class @default.
- NCIT_C185560 isDefinedBy ncit.owl @default.
- NCIT_C185560 label "CD73 Inhibitor ORIC-533" @default.
- NCIT_C185560 subClassOf NCIT_C129820 @default.
- NCIT_C185560 subClassOf NCIT_C185560 @default.
- NCIT_C185560 subClassOf NCIT_C1908 @default.
- NCIT_C185560 subClassOf NCIT_C1909 @default.
- NCIT_C185560 subClassOf NCIT_C274 @default.
- NCIT_C185560 subClassOf NCIT_C308 @default.