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- NCIT_C185597 IAO_0000115 "A topical preparation composed of a silicone gel containing a docosahexaenoic acid derivative and cytosolic group IVA phospholipase A2 alpha (cytosolic phospholipase A2 group IVA; cPLA2a; GIVA cPLA2; Group IVA cPLA2) inhibitor, with potential anti-inflammatory activity. Upon topical application to the affected site(s), the cPLA2 inhibiting silicone-based gel AVX001 binds to and inhibits the activity of cPLA2alpha. This may inhibit cPLA2alpha-mediated inflammation. cPLA2alpha catalyzes the release of arachidonic acid from glycerophospholipids and plays a key role in various inflammatory diseases. It is overexpressed in certain cancer cells and may play a key role in proliferation, migration, and chemo-resistance." @default.
- NCIT_C185597 NCIT_A7 NCIT_C19836 @default.
- NCIT_C185597 NCIT_NHC0 "C185597" @default.
- NCIT_C185597 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185597 NCIT_P108 "cPLA2 Inhibiting Silicone-based Gel AVX001" @default.
- NCIT_C185597 NCIT_P208 "CL1773945" @default.
- NCIT_C185597 NCIT_P322 "GDC" @default.
- NCIT_C185597 NCIT_P399 "808342" @default.
- NCIT_C185597 normalizedInformationContent "100" @default.
- NCIT_C185597 referenceCount "1" @default.
- NCIT_C185597 hasExactSynonym "(6E,10Z,13Z,16Z,19Z)-1,1,1-trifluoro-4-thiadocosa-6,10,13,16,19-pentaen-2-one" @default.
- NCIT_C185597 hasExactSynonym "AVX 001" @default.
- NCIT_C185597 hasExactSynonym "AVX-001" @default.
- NCIT_C185597 hasExactSynonym "AVX001" @default.
- NCIT_C185597 hasExactSynonym "Silicone-based Gel AVX001" @default.
- NCIT_C185597 hasExactSynonym "cPLA2 Inhibiting Silicone-based Gel AVX001" @default.
- NCIT_C185597 inSubset NCIT_C128784 @default.
- NCIT_C185597 inSubset NCIT_C157711 @default.
- NCIT_C185597 inSubset NCIT_C157712 @default.
- NCIT_C185597 inSubset NCIT_C176424 @default.
- NCIT_C185597 type Class @default.
- NCIT_C185597 isDefinedBy ncit.owl @default.
- NCIT_C185597 label "cPLA2 Inhibiting Silicone-based Gel AVX001" @default.
- NCIT_C185597 subClassOf NCIT_C185597 @default.
- NCIT_C185597 subClassOf NCIT_C1908 @default.
- NCIT_C185597 subClassOf NCIT_C1909 @default.
- NCIT_C185597 subClassOf NCIT_C29629 @default.
- NCIT_C185597 subClassOf NCIT_C29639 @default.