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- NCIT_C1856 IAO_0000115 "A nonsedating benzodiazepine derivative with potential antineoplastic activity. Farnesyltransferase inhibitor BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cells with and without Ras mutations." @default.
- NCIT_C1856 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1856 NCIT_A7 NCIT_C17526 @default.
- NCIT_C1856 NCIT_NHC0 "C1856" @default.
- NCIT_C1856 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1856 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1856 NCIT_P107 "BMS-214662" @default.
- NCIT_C1856 NCIT_P108 "BMS-214662" @default.
- NCIT_C1856 NCIT_P175 "710086" @default.
- NCIT_C1856 NCIT_P207 "C1306120" @default.
- NCIT_C1856 NCIT_P210 "195987-41-8" @default.
- NCIT_C1856 NCIT_P319 "L2U9GFD244" @default.
- NCIT_C1856 NCIT_P322 "CTRP" @default.
- NCIT_C1856 NCIT_P322 "FDA" @default.
- NCIT_C1856 NCIT_P322 "GDC" @default.
- NCIT_C1856 NCIT_P325 "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors." @default.
- NCIT_C1856 NCIT_P329 "37852" @default.
- NCIT_C1856 NCIT_P330 "37852" @default.
- NCIT_C1856 NCIT_P366 "BMS214662" @default.
- NCIT_C1856 NCIT_P375 "BMS-214662" @default.
- NCIT_C1856 NCIT_P399 "37852" @default.
- NCIT_C1856 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C1856 NCIT_R125 NCIT_C19903 @default.
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- NCIT_C1856 NCIT_R125 NCIT_C21198 @default.
- NCIT_C1856 NCIT_R125 NCIT_C28498 @default.
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- NCIT_C1856 NCIT_R125 NCIT_C51037 @default.
- NCIT_C1856 NCIT_R146 NCIT_C17526 @default.
- NCIT_C1856 NCIT_R146 NCIT_C21176 @default.
- NCIT_C1856 NCIT_R146 NCIT_C26548 @default.
- NCIT_C1856 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C1856 referenceCount "3" @default.
- NCIT_C1856 hasExactSynonym "7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine" @default.
- NCIT_C1856 hasExactSynonym "BMS-214662" @default.
- NCIT_C1856 hasExactSynonym "FTI BMS 214662" @default.
- NCIT_C1856 inSubset NCIT_C116977 @default.
- NCIT_C1856 inSubset NCIT_C116978 @default.
- NCIT_C1856 inSubset NCIT_C128784 @default.
- NCIT_C1856 inSubset NCIT_C157711 @default.
- NCIT_C1856 inSubset NCIT_C157712 @default.
- NCIT_C1856 inSubset NCIT_C176424 @default.
- NCIT_C1856 inSubset NCIT_C177537 @default.
- NCIT_C1856 inSubset NCIT_C63923 @default.
- NCIT_C1856 type Class @default.
- NCIT_C1856 isDefinedBy ncit.owl @default.
- NCIT_C1856 label "BMS-214662" @default.
- NCIT_C1856 subClassOf B328dc33abe3c9b34ae0b007a872d51e5 @default.
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- NCIT_C1856 subClassOf NCIT_C1856 @default.
- NCIT_C1856 subClassOf NCIT_C1908 @default.
- NCIT_C1856 subClassOf NCIT_C1909 @default.
- NCIT_C1856 subClassOf NCIT_C2020 @default.
- NCIT_C1856 subClassOf NCIT_C471 @default.