Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C185602> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- NCIT_C185602 IAO_0000115 "A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human T-cell surface antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD3/anti-CLDN18.2 bispecific antibody IBI389 simultaneously binds to both CD3-expressing T-cells and CLDN18.2-expressing cancer cells, thereby crosslinking CLDN18.2-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C185602 NCIT_A7 NCIT_C150412 @default.
- NCIT_C185602 NCIT_NHC0 "C185602" @default.
- NCIT_C185602 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185602 NCIT_P108 "Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389" @default.
- NCIT_C185602 NCIT_P208 "CL1773946" @default.
- NCIT_C185602 NCIT_P322 "GDC" @default.
- NCIT_C185602 NCIT_P399 "808408" @default.
- NCIT_C185602 NCIT_R124 NCIT_C17710 @default.
- NCIT_C185602 NCIT_R124 NCIT_C17828 @default.
- NCIT_C185602 NCIT_R124 NCIT_C18219 @default.
- NCIT_C185602 NCIT_R124 NCIT_C19986 @default.
- NCIT_C185602 NCIT_R124 NCIT_C40474 @default.
- NCIT_C185602 normalizedInformationContent "100" @default.
- NCIT_C185602 referenceCount "1" @default.
- NCIT_C185602 hasExactSynonym "Anti-CD3/Anti-CLDN18.2 Bispecific Antibody IBI389" @default.
- NCIT_C185602 hasExactSynonym "Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389" @default.
- NCIT_C185602 hasExactSynonym "Anti-CLDN18.2/Anti-CD3 Bispecific Antibody IBI389" @default.
- NCIT_C185602 hasExactSynonym "Anti-Claudin18.2/CD3 Bispecific Antibody IBI389" @default.
- NCIT_C185602 hasExactSynonym "CLDN18.2 x CD3 Bispecific Antibody IBI389" @default.
- NCIT_C185602 hasExactSynonym "IBI 389" @default.
- NCIT_C185602 hasExactSynonym "IBI-389" @default.
- NCIT_C185602 hasExactSynonym "IBI389" @default.
- NCIT_C185602 inSubset NCIT_C128784 @default.
- NCIT_C185602 inSubset NCIT_C157711 @default.
- NCIT_C185602 inSubset NCIT_C157712 @default.
- NCIT_C185602 inSubset NCIT_C176424 @default.
- NCIT_C185602 type Class @default.
- NCIT_C185602 isDefinedBy ncit.owl @default.
- NCIT_C185602 label "Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389" @default.
- NCIT_C185602 subClassOf NCIT_C112883 @default.
- NCIT_C185602 subClassOf NCIT_C129821 @default.
- NCIT_C185602 subClassOf NCIT_C129822 @default.
- NCIT_C185602 subClassOf NCIT_C1454 @default.
- NCIT_C185602 subClassOf NCIT_C163758 @default.
- NCIT_C185602 subClassOf NCIT_C179676 @default.
- NCIT_C185602 subClassOf NCIT_C185602 @default.
- NCIT_C185602 subClassOf NCIT_C1908 @default.
- NCIT_C185602 subClassOf NCIT_C1909 @default.
- NCIT_C185602 subClassOf NCIT_C200250 @default.
- NCIT_C185602 subClassOf NCIT_C201282 @default.
- NCIT_C185602 subClassOf NCIT_C20401 @default.
- NCIT_C185602 subClassOf NCIT_C274 @default.
- NCIT_C185602 subClassOf NCIT_C28227 @default.
- NCIT_C185602 subClassOf NCIT_C307 @default.
- NCIT_C185602 subClassOf NCIT_C308 @default.