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- NCIT_C185607 IAO_0000115 "A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 CAR T cells IBI345 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C185607 NCIT_A7 NCIT_C150412 @default.
- NCIT_C185607 NCIT_NHC0 "C185607" @default.
- NCIT_C185607 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185607 NCIT_P108 "Anti-Claudin18.2 CAR T Cells IBI345" @default.
- NCIT_C185607 NCIT_P208 "CL1773938" @default.
- NCIT_C185607 NCIT_P322 "GDC" @default.
- NCIT_C185607 NCIT_P399 "808411" @default.
- NCIT_C185607 normalizedInformationContent "100" @default.
- NCIT_C185607 referenceCount "1" @default.
- NCIT_C185607 hasExactSynonym "Anti-CLDN18.2 CAR T Cells IBI345" @default.
- NCIT_C185607 hasExactSynonym "Anti-Claudin18.2 CAR T Cells IBI345" @default.
- NCIT_C185607 hasExactSynonym "IBI 345" @default.
- NCIT_C185607 hasExactSynonym "IBI-345" @default.
- NCIT_C185607 hasExactSynonym "IBI345" @default.
- NCIT_C185607 inSubset NCIT_C128784 @default.
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- NCIT_C185607 type Class @default.
- NCIT_C185607 isDefinedBy ncit.owl @default.
- NCIT_C185607 label "Anti-Claudin18.2 CAR T Cells IBI345" @default.
- NCIT_C185607 subClassOf NCIT_C129820 @default.
- NCIT_C185607 subClassOf NCIT_C129821 @default.
- NCIT_C185607 subClassOf NCIT_C129826 @default.
- NCIT_C185607 subClassOf NCIT_C137999 @default.
- NCIT_C185607 subClassOf NCIT_C142078 @default.
- NCIT_C185607 subClassOf NCIT_C154231 @default.
- NCIT_C185607 subClassOf NCIT_C185607 @default.
- NCIT_C185607 subClassOf NCIT_C1908 @default.
- NCIT_C185607 subClassOf NCIT_C1909 @default.
- NCIT_C185607 subClassOf NCIT_C1962 @default.
- NCIT_C185607 subClassOf NCIT_C201172 @default.
- NCIT_C185607 subClassOf NCIT_C274 @default.
- NCIT_C185607 subClassOf NCIT_C307 @default.
- NCIT_C185607 subClassOf NCIT_C308 @default.