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- NCIT_C185613 IAO_0000115 "An orally bioavailable selective inhibitor of the ubiquitin specific protease 1 (USP1), with apoptosis-inducing, tumor-sensitizing and antineoplastic activities. Upon oral administration, USP1 inhibitor KSQ-4279 specifically binds to and inhibits the activity of USP1, thereby blocking USP1-mediated deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of mono-ubiquinated substrates. This induces the unfolded protein response (UPR). This may induce cell cycle arrest, reduce the expression of certain anti-apoptotic proteins, induce tumor cell apoptosis, inhibit tumor cell growth, and may sensitize tumor cells to DNA-targeting chemotherapeutics. USP1, a deubiquitinating enzyme overexpressed in various tumor cell types, plays a key role in the correct folding and deubiquitination of proteins and facilitates DNA repair via its role regulating the Fanconi anemia complex and translesion synthesis." @default.
- NCIT_C185613 NCIT_A7 NCIT_C185668 @default.
- NCIT_C185613 NCIT_NHC0 "C185613" @default.
- NCIT_C185613 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185613 NCIT_P107 "USP1 inhibitor KSQ-4279" @default.
- NCIT_C185613 NCIT_P108 "USP1 inhibitor KSQ-4279" @default.
- NCIT_C185613 NCIT_P208 "CL1773874" @default.
- NCIT_C185613 NCIT_P319 "HK5F3RGM8P" @default.
- NCIT_C185613 NCIT_P322 "CTRP" @default.
- NCIT_C185613 NCIT_P322 "FDA" @default.
- NCIT_C185613 NCIT_P322 "GDC" @default.
- NCIT_C185613 NCIT_P399 "809247" @default.
- NCIT_C185613 normalizedInformationContent "100" @default.
- NCIT_C185613 referenceCount "1" @default.
- NCIT_C185613 hasExactSynonym "KSQ 4279" @default.
- NCIT_C185613 hasExactSynonym "KSQ-4279" @default.
- NCIT_C185613 hasExactSynonym "KSQ4279" @default.
- NCIT_C185613 hasExactSynonym "USP1 inhibitor KSQ-4279" @default.
- NCIT_C185613 hasExactSynonym "Ubiquitin Specific Protease 1 Inhibitor KSQ-4279" @default.
- NCIT_C185613 inSubset NCIT_C116977 @default.
- NCIT_C185613 inSubset NCIT_C116978 @default.
- NCIT_C185613 inSubset NCIT_C128784 @default.
- NCIT_C185613 inSubset NCIT_C157711 @default.
- NCIT_C185613 inSubset NCIT_C157712 @default.
- NCIT_C185613 inSubset NCIT_C176424 @default.
- NCIT_C185613 inSubset NCIT_C63923 @default.
- NCIT_C185613 type Class @default.
- NCIT_C185613 isDefinedBy ncit.owl @default.
- NCIT_C185613 label "USP1 inhibitor KSQ-4279" @default.
- NCIT_C185613 subClassOf NCIT_C163758 @default.
- NCIT_C185613 subClassOf NCIT_C185613 @default.
- NCIT_C185613 subClassOf NCIT_C1908 @default.
- NCIT_C185613 subClassOf NCIT_C1909 @default.
- NCIT_C185613 subClassOf NCIT_C2160 @default.
- NCIT_C185613 subClassOf NCIT_C274 @default.
- NCIT_C185613 subClassOf NCIT_C471 @default.